Effects of platelet rich fibrin alone used with rigid titanium barrier
| Autor: | Seref Ezirganli, Ahmet Mihmanli, M. Isa Kara, Emre Barış, Hakan Ozdemir |
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| Přispěvatelé: | ÖZDEMİR, MEHMET HAKAN, [Ozdemir, Hakan] Cumhuriyet Univ, Fac Dent, Dept Periodontol, Sivas, Turkey -- [Ezirganli, Seref -- Mihmanli, Ahmet] Bezmialem Vakif Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Istanbul, Turkey -- [Kara, M. Isa] Izmir Katip Celebi Univ, Fac Dent, Dept Oral & Maxillofacial Surg, TR-35180 Izmir, Turkey -- [Baris, Emre] Gazi Univ, Fac Dent, Dept Oral Pathol, Ankara, Turkey |
| Rok vydání: | 2013 |
| Předmět: |
Blood Platelets
Male Guided bone regeneration Bone Regeneration Platelet-derived growth factor Titanium barrier Dentistry chemistry.chemical_element Calvaria Rabbit Biphasic calcium phosphate Fibrin chemistry.chemical_compound medicine Animals Platelet Bone regeneration General Dentistry Anorganic bovine bone Platelet-Derived Growth Factor Titanium Bone Transplantation biology business.industry Skull Membranes Artificial Cell Biology General Medicine Platelet-rich fibrin digestive system diseases medicine.anatomical_structure Otorhinolaryngology chemistry Platelet-rich plasma Bone Substitutes Guided Tissue Regeneration Periodontal biology.protein Hydroxyapatites Rabbits business Platelet rich fibrin |
| Popis: | WOS: 000318322000013 PubMed ID: 23141995 Objective: Platelet-rich fibrin (PRF) is a platelet and leukocyte rich and platelet preparation that concentrates various growth factors and therefore has the potential to be used as regenerative treatment. The aim of study was to assess the effects of platelet rich fibrin (PRF) on bone augmentation when used in conjunction with titanium barrier a rabbit calvaria model. Study design: Twenty-four adult male New Zealand rabbits were used in this study. Two titanium barriers were fixed on each rabbit's calvarium. The rabbits were divided into four groups (group one is control and the other three groups are experimental) and each group contains 6 animals. PRF, anorganic bovine bone (ABB), and biphasic calcium phosphate (BCP) were used with titanium barriers in the experimental groups. Any materials were not used in the control group. Half of the animals were sacrificed after 1 month, and the rest were sacrificed after 3 months. Histomorphometric evaluation was carried out in order to compare new bone formation among the groups. Results: Significantly more new bone area was noted in the PRF alone group than in the control group, no statistically significant differences were found among PRF, BCP and ABB groups after 1 month. PRF and ABB also had superior effects in new bone formation area control to the BCP group after 3 months. Conclusion: PRF may offer the ease of use, simple handling, and enhanced delivery of growth factors during the bone augmentation procedures. When used in conjunction with the titanium barriers, PEP use can increase the quality of the newly formed bone and enhance the rate of bone formation due to the concentration of growth factors. (C) 2012 Elsevier Ltd. All rights reserved. Cumhuriyet University [DIS-080] This work was supported by the Scientific Research Project Fund of Cumhuriyet University under the project number DIS-080. |
| Databáze: | OpenAIRE |
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