Pancreatic Exocrine Insufficiency in Pancreatic Cancer
| Autor: | Johan Permert, J.-Matthias Löhr, Roberto Valente, Marco Del Chiaro, Miroslav Vujasinovic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
exocrine insufficiency media_common.quotation_subject pancreatic cancer lcsh:TX341-641 Review malnutrition Gastroenterology Cachexia 03 medical and health sciences 0302 clinical medicine pancreas cancer Weight loss Internal medicine Pancreatic cancer medicine Humans Enzyme Replacement Therapy pancreas pancreatic surgery media_common Randomized Controlled Trials as Topic pancreatic exocrine insufficiency Nutrition and Dietetics business.industry vitamin Cancer Appetite Vitamins medicine.disease Warburg effect Pancreatic Neoplasms Malnutrition Endocrinology medicine.anatomical_structure exocrine insufficiency pancreas pancreas cancer 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Exocrine Pancreatic Insufficiency medicine.symptom Pancreas business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Nutrients, Vol 9, Iss 3, p 183 (2017) |
| ISSN: | 2072-6643 |
| Popis: | Cancer patients experience weight loss for a variety of reasons, commencing with the tumor’s metabolism (Warburg effect) and proceeding via cachexia to loss of appetite. In pancreatic cancer, several other factors are involved, including a loss of appetite with a particular aversion to meat and the incapacity of the pancreatic gland to function normally when a tumor is present in the pancreatic head. Pancreatic exocrine insufficiency is characterized by a deficiency of the enzymes secreted from the pancreas due to the obstructive tumor, resulting in maldigestion. This, in turn, contributes to malnutrition, specifically a lack of fat-soluble vitamins, antioxidants, and other micronutrients. Patients with pancreatic cancer and pancreatic exocrine insufficiency have, overall, an extremely poor prognosis with regard to surgical outcome and overall survival. Therefore, it is crucial to be aware of the mechanisms involved in the disease, to be able to diagnose pancreatic exocrine insufficiency early on, and to treat malnutrition appropriately, for example, with pancreatic enzymes. |
| Databáze: | OpenAIRE |
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