A New Model of the Human Atrial Myocyte with Variable T:tubule Organization for the Study of Atrial Fibrillation
| Autor: | Antony J. Workman, Niall MacQuiaide, Michael A. Colman, Prasanna Partha Sarathy |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry T-tubule organization Atrial fibrillation Calcium cycling medicine.disease 03 medical and health sciences Electrophysiology 030104 developmental biology Intracellular structure Calcium dynamics Internal medicine cardiovascular system medicine Cardiology Calcium Waves cardiovascular diseases Atrial myocytes business |
| Zdroj: | CinC |
| ISSN: | 2325-887X 0276-6574 |
| Popis: | Atrial fibrillation is the most common arrhythmia, yet\ud treatment strategies are sub-optimal due to incomplete\ud understanding of the underlying mechanisms. Spatiotemporal\ud sub-cellular calcium cycling may play a critical\ud role in the development of alternans and spontaneous\ud activity, which may underlie arrhythmia in the human\ud atria.\ud In this study, we construct a novel electrophysiological\ud model of the human atrial myocyte which incorporates new\ud data on atrial intracellular structure and explicitly\ud accounts for variations in T-tubule organization.\ud The model reproduces spatio-temporal calcium\ud dynamics associated with normal cardiac excitation. In\ud preliminary simulations, the model demonstrates that a\ud loss of T-tubules can promote both alternans and\ud spontaneous calcium waves.\ud The model produced in this study provides novel insight\ud into arrhythmia mechanisms in the human atria and\ud provides a platform for future investigation of proarrhythmic\ud calcium dynamics. |
| Databáze: | OpenAIRE |
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