The Pathophysiology of Smoke Inhalation Injury in a Sheep Model
| Autor: | H. A. Linares, D. N. Herndon, Lillian D. Traber, G. D. Niehaus, Daniel L. Traber |
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| Rok vydání: | 1984 |
| Předmět: |
Pathology
medicine.medical_specialty Smoke Inhalation Injury Partial Pressure Pulmonary Edema Vascular permeability Critical Care and Intensive Care Medicine Capillary Permeability medicine Animals Protease Inhibitors Lung Mucous Membrane Sheep Inhalation business.industry Respiratory disease medicine.disease Pulmonary edema Oxygen tension Oxygen medicine.anatomical_structure Neutrophil degranulation Female Surgery business Burns Inhalation |
| Zdroj: | The Journal of Trauma: Injury, Infection, and Critical Care. 24:1044-1051 |
| ISSN: | 0022-5282 |
| Popis: | This study describes an experimental model of smoke inhalation injury in sheep, in which the same pathophysiologic alterations occur as with clinical inhalation in man. Both the patients and the experimental sheep develop diffuse pulmonary mucosal sloughing, pulmonary edema, and a decrease in systemic oxygen tension. The results of this study indicate that the pulmonary edema is the result of an increase in microvascular permeability, characterized by increases in lung lymph flow (Qlym), lymph-to-plasma protein concentration ratio (L/P), and transvascular protein flux (Qlym X lung lymph protein concentration), while pulmonary vascular pressures remain constant. Neutrophil degranulation may contribute to the increased microvascular permeability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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