The effect of clofazimine on the pharmacokinetics of rifampicin and dapsone in leprosy
| Autor: | Bharadwaj Vp, B. K. Girdhar, Anil Mathur, Venkatesan K |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Antibiotics Pharmacology Dapsone Clofazimine Pharmacokinetics Leprosy polycyclic compounds medicine Humans Pharmacology (medical) Lepromatous leprosy business.industry Drug interaction bacterial infections and mycoses medicine.disease Kinetics Infectious Diseases Rifampin business Rifampicin Half-Life medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 18:715-718 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/18.6.715 |
| Popis: | Fifteen untreated leprosy patients were given rifampicin and dapsone for seven days, and then rifampicin, dapsone and clofazimine for seven days. Concentrations of rifampicin and dapsone were estimated in timed plasma specimens and in 24 h urine specimens on days 7 and 14. No significant differences in the pharmacokinetics of rifampicin and dapsone were observed between the two occasions of sampling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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