Treatment of Hepatitis C with Direct-Acting Antivirals does not Induce Significant Arrhythmias
| Autor: | Williane Emanuelle Rodrigues Costa, Norma Arteiro Filgueira, André Gustavo da Silva Rezende, Andrea Dória Batista, Poline Maria de Sousa Felix, Edmundo Pessoa de Almeida Lopes, Brivaldo Markman Filho |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cirrhosis 02 engineering and technology DIRECT ACTING ANTIVIRALS QT interval Antiviral Agents Arrhythmias Cardiacs QRS complex chemistry.chemical_compound Internal medicine Heart rate 0202 electrical engineering electronic engineering information engineering medicine PR interval business.industry Ribavirin 020206 networking & telecommunications Hepatitis C Sofosbuvir/ therapeutic use medicine.disease Drug Resistance Viral chemistry Cardiology cardiovascular system Hepatitis C/treatment 020201 artificial intelligence & image processing business |
| Zdroj: | International Journal of Cardiovascular Sciences, Issue: ahead, Published: 23 JUN 2021 International Journal of Cardiovascular Sciences v.35 n.5 2022 International Journal of Cardiovascular Sciences Sociedade Brasileira de Cardiologia (SBC) instacron:SBC International Journal of Cardiovascular Sciences, Volume: 35, Issue: 5, Pages: 578-584, Published: 23 JUN 2021 |
| Popis: | Background Chronic Hepatitis C (CHC) therapy with direct-acting antivirals (DAAs) has high efficacy and safety, but some cases of bradyarrhythmias have been described. Objective To evaluate heart rhythm disorders during DAA treatments. Methods Forty-eight patients with CHC (mean 61 years of age; 56% males; 73% HCV genotype 1) were evaluated before and during treatment with DAAs, analyzed by a resting 12-lead ECG [PR, QRS, and QT corrected (QTc) intervals measured] and a 24-h-Holter system, to evaluate the heart rate (HR) and the occurrence of arrhythmias. The Student’s t-test or the Wilcoxon-Mann-Whitney test for continuous, independent variables were performed with a statistically significant p-value < 0.05. Results The electrocardiographic parameters before and during treatment were: PR interval (147.2 ± 15.6 vs 144.9 ± 15.6 ms; p = 0.21), QTc interval (427 ± 22.3 vs 421.7 ± 25.3 ms; p = 0.24), minimum HR (52.7 ± 8.4 vs 53.2 ± 8.5 bpm; p = 0.49), median HR (74.2 ± 10.4 vs 75.2 ± 9 bpm; p = 0.83), and maximum HR (117.4 ± 16.8 vs 117.9 ± 16.3 bpm; p = 0.25). These parameters proved to be similar among 11 beta-blockers or 22 ribavirin users. During treatment, the 21 cirrhotic patients presented significantly lower median HRs (72.1 ± 9.0 vs 77.9 ± 8.2 bpm; p = 0.02) and maximum HRs (108.9 ± 15.2 vs. 125.1 ± 13.2 bpm, p < 0.0001) through a 24-h-Holter monitoring than the patients without cirrhosis. No clinically relevant arrhythmias were detected. Conclusion DAAs do not significantly influence heart rate or induce significant cardiac arrhythmias in patients with CHC. |
| Databáze: | OpenAIRE |
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