Imidazole-induced contractility of vascular smooth muscle cells in the presence of U-73122, ODQ, indomethacin and 7-nitroindazole
| Autor: | A.T. Sinjab, Marek Krzyżanowski, Elżbieta Grześk, Grzegorz Grześk, Bartosz Malinowski, Michał Wiciński, Katarzyna Szadujkis-Szadurska, J. Dzięcioł, Dorota Bylina, Anna Czeczuk, Agnieszka Michalska |
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| Rok vydání: | 2013 |
| Předmět: |
Indazoles
Vascular smooth muscle 7-Nitroindazole Phosphodiesterase Inhibitors medicine.medical_treatment Indomethacin Myocytes Smooth Muscle Intraperitoneal injection Receptors Cytoplasmic and Nuclear Pharmacology Muscle Smooth Vascular Contractility chemistry.chemical_compound Soluble Guanylyl Cyclase Indometacin medicine Animals Enzyme Inhibitors Estrenes Receptor Oxadiazoles General Veterinary Chemistry Anti-Inflammatory Agents Non-Steroidal Imidazoles General Medicine Pyrrolidinones Rats medicine.anatomical_structure Guanylate Cyclase Vasoconstriction Vascular resistance medicine.symptom Muscle contraction medicine.drug |
| Zdroj: | Polish Journal of Veterinary Sciences. 16:293-297 |
| ISSN: | 1505-1773 |
| Popis: | The aim of the study was to assess the impact of modulating factors on vascular smooth muscle cells reactivity. Vascular resistance was induced by the administration of increasing concentrations of imidazole. The experiments were performed on isolated and perfused tail artery of Wistar rats (weight 250 g - 350 g). Rats were been narcotized by urethane (intraperitoneal injection) at a dose of 120 mg/kg, stunned and then sacrificed by cervical dislocation. In the following investigation classical pharmacometric methods were used. Relationships between concentration-response curves (CRCs) for imidazole observed in the presence of ODQ [(1H-(1,2,4)oxadiazolo-[4,3-a]quinoxalin-1-one)], 7-nitroindazole and indomethacin were analyzed. Imidazole-induced contractility of vascular smooth muscle cells was independent from alpha- adrenergic receptors and PLC activity. Reactivity of VSMCsinduced by imidazole, was significantly changed in the presence of ODQ and 7-nitroindazole. |
| Databáze: | OpenAIRE |
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