Effects of Spironolactone on Hypoxia-Inducible Factor-1α in the Patients Receiving Coronary Artery Bypass Grafting
| Autor: | Wen-Jun Shen, Zhe-Lan Zheng, Jianqing Zhou, Lin-Yuan Xie, Yu-Mei Lou, De-Xing Hu, Jiangfang Lian, Guo-Feng Shao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Cardiac function curve medicine.medical_specialty Time Factors medicine.drug_class Spironolactone chemistry.chemical_compound Risk Factors Internal medicine Atrial Fibrillation Natriuretic Peptide Brain Troponin I Natriuretic peptide Humans Medicine cardiovascular diseases Coronary Artery Bypass Aged Mineralocorticoid Receptor Antagonists Retrospective Studies Aged 80 and over Pharmacology business.industry Incidence (epidemiology) Coronary Stenosis Atrial fibrillation Middle Aged Hypoxia-Inducible Factor 1 alpha Subunit medicine.disease Peptide Fragments Treatment Outcome surgical procedures operative medicine.anatomical_structure chemistry Propensity score matching Cardiology Female Cardiology and Cardiovascular Medicine business Biomarkers Artery |
| Zdroj: | Journal of Cardiovascular Pharmacology. 78:e101-e104 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/fjc.0000000000001040 |
| Popis: | We explored the protective effect of spironolactone on cardiac function in the patients undergoing coronary artery bypass grafting (CABG) by determining serum hypoxia-inducible factor-1α (HIF-1α) before and after CABG. We used the propensity score matching method retrospectively to select 174 patients undergoing CABG in our hospital from March 2018 to December 2019. Of the 174 patients, 87 patients taking spironolactone for more than 3 months before CABG were used as a test group and other 87 patients who were not taking spironolactone as a control group. In all patients, serum HIF-1α and troponin I levels were determined before as well as 24 hours and 7 days after CABG, serum N-terminal probrain natriuretic peptide (NT-proBNP) level was determined before as well as 12, 24, and 36 hours after CABG, and electrocardiographic monitoring was performed within 36 hours after CABG. The results indicated that there were no significant differences in the HIF-1α level between the test group and the control group before and 7 days after CABG, but the HIF-1α level was significantly lower in the test group than that in the control group 24 hours after CABG (P < 0.01). The 2 groups were not significantly different in the troponin I level at any time point. There was no significant difference in the serum NT-proBNP level between the test group and the control group before CABG, but NT-proBNP (BNP) levels were all significantly lower in the test group than those in the control group at postoperative 12, 24, and 36 hour time points (all P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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