Podoplanin expression in cancer-associated fibroblasts predicts unfavorable prognosis in node-negative breast cancer patients with hormone receptor-positive/HER2 - negative subtype
| Autor: | Kanae Nosaka, Takashi Ohno, Taichi Kadonaga, Tomohiko Sakabe, Makoto Wakahara, Hiroshige Nakamura, Yuko Tanaka, Yoshimasa Suzuki, Yoshiteru Kidokoro, Yoshihisa Umekita |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Adult medicine.medical_specialty Lymphovascular invasion Receptor ErbB-2 Breast Neoplasms Kaplan-Meier Estimate Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Breast cancer Lymphocytes Tumor-Infiltrating Cancer-Associated Fibroblasts Surgical oncology Internal medicine Biomarkers Tumor Medicine Humans Pharmacology (medical) Radiology Nuclear Medicine and imaging Aged Retrospective Studies Univariate analysis Membrane Glycoproteins business.industry Hazard ratio General Medicine Middle Aged medicine.disease 030104 developmental biology Podoplanin Invasive carcinoma of no special type 030220 oncology & carcinogenesis Lymphatic Metastasis Immunohistochemistry Female business |
| Zdroj: | Breast cancer (Tokyo, Japan). 28(4) |
| ISSN: | 1880-4233 |
| Popis: | Podoplanin expression in cancer-associated fibroblasts (CAFs) has been proposed as an indicator for poor prognosis in patients with invasive breast carcinomas, but little is known about its clinical significance in node-negative breast cancer patients with hormone receptor (HR) + /HER2 − subtype, who are expected to have a favorable prognosis. Immunohistochemical analyses were performed on 169 resected specimens of node-negative invasive carcinoma of no special type with HR + /HER2 − subtype using antibodies for podoplanin. When more than 10% of CAFs showed immunoreactivity with podoplanin as strong as that of internal positive controls, the specimens were judged as podoplanin-positive. Podoplanin-positive status in CAFs was observed in 16.0% (27 of 169 cases) and it associated with high Ki67 labeling index (LI) (> 30%) (p = 0.03), higher stromal tumor-infiltrating lymphocytes (p |
| Databáze: | OpenAIRE |
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