A long-term clinical trial of interferon alpha-therapy in essential thrombocythemia
| Autor: | I. Boll, G. Middelhoff |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Alpha interferon Interferon alpha-2 Gastroenterology Interferon Internal medicine medicine Humans Interferon alfa Hematology Thrombocytosis Maintenance dose Essential thrombocythemia business.industry Platelet Count Interferon-alpha General Medicine Middle Aged medicine.disease Recombinant Proteins Concomitant Immunology Female business medicine.drug Follow-Up Studies Thrombocythemia Essential |
| Zdroj: | Annals of hematology. 64(5) |
| ISSN: | 0939-5555 |
| Popis: | In a prospective clinical trial involving six patients suffering from essential thrombocythemia (ET), recombinant human interferon alpha 2 b significantly and consistently lowered highly elevated peripheral platelet numbers over long time periods. One patient has now been on continuous treatment for 4 years. During the treatment phase none of the patients suffered from bleeding episodes, thrombosis or disturbances of the micro-circulation. The interferon maintenance dose varies considerably from patient to patient, but it is usually much lower than the induction dose. One of the patients had to be with-drawn from the study due to interferon-specific chronic toxicity concomitant with the development of non-neutralizing interferon antibodies. With the exception of one patient, stopping interferon treatment led to an increase in peripheral platelet numbers of up to one million cells per microliter of blood within 4 to 12 weeks. We conclude that interferon alpha can correct peripheral thrombocytosis in selected patients with essential thrombocythemia over a period of years and prevent moribidity attributable to this disease. |
| Databáze: | OpenAIRE |
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