MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder
Autor: | Song Jiang, Ziru Liu, Qiong Zou, Jinghe Li, Zhulin Yang, Lufeng Liang, Yuan Yuan, Senlin Chen, Daiqiang Li, Meigui Chen |
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Rok vydání: | 2016 |
Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Adenosquamous carcinoma Kaplan-Meier Estimate Adenocarcinoma Biology Biochemistry neoplasm metastasis Carcinoma Adenosquamous 03 medical and health sciences MCM2 0302 clinical medicine Acetyltransferases Biomarkers Tumor Genetics medicine Carcinoma Humans Gallbladder cancer Molecular Biology TIP30 Aged Neoplasm Staging Aged 80 and over Oncogene Gallbladder Cancer Minichromosome Maintenance Complex Component 2 Articles Middle Aged gallbladder neoplasms Prognosis medicine.disease Gene Expression Regulation Neoplastic medicine.anatomical_structure Oncology Lymphatic Metastasis 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research Molecular Medicine Immunohistochemistry Female 030211 gastroenterology & hepatology Transcription Factors |
Zdroj: | Molecular Medicine Reports |
ISSN: | 1791-3004 1791-2997 |
Popis: | The clinicopathological and biological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) of the gallbladder remain to be fully elucidated, due to the fact that it is a rare gallbladder cancer subtype. In the current study, the expression of minichromosome maintenance complex component 2 (MCM2) and HIV‑1 tat interactive protein 2 (TIP30) was measured in 46 cases of SC/ASC and 80 adenocarcinomas (AC) using immunohistochemistry. Positive MCM2 and negative TIP30 expression were significantly associated with large tumor size, high TNM stage, invasion, lymph node metastasis and lack of surgical curability in SC/ASC and AC. Positive MCM2 and negative TIP30 expression were significantly associated with poor differentiation in AC, whereas only MCM2 was correlated with differentiation in SC/ASC. Univariate Kaplan‑Meier analysis demonstrated that positive MCM2 and negative TIP30 expression, the degree of differentiation, tumor size, TNM stage, invasion, lymph node metastasis and surgical curability were significantly associated with post‑operative survival in patients with SC/ASC and AC. Multivariate Cox regression analysis demonstrated that positive MCM2 and negative TIP30 expression, the degree of differentiation, tumor size, TNM stage, invasion, lymph node metastasis and lack of surgical curability were also independent predictors of poor prognosis in patients with SC/ASC and AC. These data suggest that positive MCM2 and negative TIP30 expression are closely correlated with the clinical, pathological and biological parameters, in addition to poor prognosis in patients with gallbladder cancer. |
Databáze: | OpenAIRE |
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