MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder

Autor: Song Jiang, Ziru Liu, Qiong Zou, Jinghe Li, Zhulin Yang, Lufeng Liang, Yuan Yuan, Senlin Chen, Daiqiang Li, Meigui Chen
Rok vydání: 2016
Předmět:
Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
Adenosquamous carcinoma
Kaplan-Meier Estimate
Adenocarcinoma
Biology
Biochemistry
neoplasm metastasis
Carcinoma
Adenosquamous
03 medical and health sciences
MCM2
0302 clinical medicine
Acetyltransferases
Biomarkers
Tumor
Genetics
medicine
Carcinoma
Humans
Gallbladder cancer
Molecular Biology
TIP30
Aged
Neoplasm Staging
Aged
80 and over
Oncogene
Gallbladder
Cancer
Minichromosome Maintenance Complex Component 2
Articles
Middle Aged
gallbladder neoplasms
Prognosis
medicine.disease
Gene Expression Regulation
Neoplastic
medicine.anatomical_structure
Oncology
Lymphatic Metastasis
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Cancer research
Molecular Medicine
Immunohistochemistry
Female
030211 gastroenterology & hepatology
Transcription Factors
Zdroj: Molecular Medicine Reports
ISSN: 1791-3004
1791-2997
Popis: The clinicopathological and biological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) of the gallbladder remain to be fully elucidated, due to the fact that it is a rare gallbladder cancer subtype. In the current study, the expression of minichromosome maintenance complex component 2 (MCM2) and HIV‑1 tat interactive protein 2 (TIP30) was measured in 46 cases of SC/ASC and 80 adenocarcinomas (AC) using immunohistochemistry. Positive MCM2 and negative TIP30 expression were significantly associated with large tumor size, high TNM stage, invasion, lymph node metastasis and lack of surgical curability in SC/ASC and AC. Positive MCM2 and negative TIP30 expression were significantly associated with poor differentiation in AC, whereas only MCM2 was correlated with differentiation in SC/ASC. Univariate Kaplan‑Meier analysis demonstrated that positive MCM2 and negative TIP30 expression, the degree of differentiation, tumor size, TNM stage, invasion, lymph node metastasis and surgical curability were significantly associated with post‑operative survival in patients with SC/ASC and AC. Multivariate Cox regression analysis demonstrated that positive MCM2 and negative TIP30 expression, the degree of differentiation, tumor size, TNM stage, invasion, lymph node metastasis and lack of surgical curability were also independent predictors of poor prognosis in patients with SC/ASC and AC. These data suggest that positive MCM2 and negative TIP30 expression are closely correlated with the clinical, pathological and biological parameters, in addition to poor prognosis in patients with gallbladder cancer.
Databáze: OpenAIRE
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