Effect of progressive resistance training on persistent pain after axillary dissection in breast cancer: a randomized controlled trial
Autor: | Gunn Ammitzbøll, Pernille Envold Bidstrup, Christoffer Johansen, Susanne Oksbjerg Dalton, Kenneth Geving Andersen, Niels Kroman, Bo Zerahn, Elisabeth Wreford Andersen, Ole Hyldegaard, Charlotte Lanng |
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Rok vydání: | 2019 |
Předmět: |
Adult
0301 basic medicine Cancer Research medicine.medical_specialty Breast Neoplasms law.invention 03 medical and health sciences 0302 clinical medicine Breast cancer Randomized controlled trial law Intervention (counseling) Statistical significance Internal medicine medicine Humans Treatment Failure Aged Pain Measurement Pain Postoperative business.industry Resistance training Axillary Lymph Node Dissection Repeated measures design Resistance Training Middle Aged medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis Axilla Neuropathic pain Lymph Node Excision Female business |
Zdroj: | Breast Cancer Research and Treatment. 179:173-183 |
ISSN: | 1573-7217 0167-6806 |
Popis: | Persistent pain is a known challenge among breast cancer survivors. In secondary analyses of a randomized controlled trial, we examined the effect of progressive resistance training on persistent pain in the post-operative year in women treated for breast cancer with axillary lymph node dissection. We randomized 158 women after BC surgery with Axillary Lymph Node Dissection (ALND) (1:1) to usual care or a 1-year, supervised and self-administered, progressive resistance training intervention initiated 3 weeks after surgery. A questionnaire at baseline, 20 weeks and 12 months assessed the intensity and frequency of pain, neuropathic pain and influence of pain on aspects of daily life. We analysed the effect using linear mixed models and multinomial logistic regression models for repeated measures. A high percentage of participants experienced baseline pain (85% and 83% in the control and intervention groups respectively) and by the 12 month assessment these numbers were more than halved. A high proportion of participants also experienced neuropathic pain (88% and 89% in control and intervention group respectively), a finding that was stable throughout the study period. The effect on intensity of pain indicators favoured the exercise group, although most estimates did not reach statistical significance, with differences being small. For women who had BC surgery with ALND, our progressive resistance training intervention conferred no benefit over usual care in reducing pain. Importantly, it did not increase the risk of pain both in the short and long term rehabilitative phase. |
Databáze: | OpenAIRE |
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