Diffusion kurtosis imaging: An efficient tool for evaluating age-related changes in rat brains
| Autor: | Qingfeng Zhu, Huandi Lv, Zuojun Geng, Zhenhu Song, Xue-Fang Han |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
diffusion kurtosis imaging
External capsule Neurosciences. Biological psychiatry. Neuropsychiatry Diffusion Rats Sprague-Dawley Behavioral Neuroscience Nuclear magnetic resonance Age related medicine Animals magnetic resonance imaging Sprague–Dawley rat Diffusion Kurtosis Imaging Brain aging Original Research medicine.diagnostic_test Chemistry Brain Magnetic resonance imaging Rats medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging Cerebral cortex Laterality Kurtosis brain aging age‐related correlation analysis RC321-571 |
| Zdroj: | Brain and Behavior Brain and Behavior, Vol 11, Iss 11, Pp n/a-n/a (2021) |
| ISSN: | 2162-3279 |
| Popis: | Purpose To evaluate and determine age‐related changes in rat brains by studying the diffusion kurtosis imaging results among different age groups of rats. Methods Sprague–Dawley (SD) rats underwent conventional magnetic resonance imaging (MRI) and diffusion Kurtosis Imaging (DKI). Two diffusion values of mean kurtosis (MK) and kurtosis (K⊥) were measured and analyzed based on laterality, brain regions and age groups. The MK and K⊥ data were plotted against different age groups. Results No laterality was found for the MK or K⊥ values in the cerebral cortex (CT), external capsule (EC), or caudate putamen (CPu) regions. In contrast, significant changes in these values were observed among different age groups. Changes of the MK and K⊥ values were significant in both hemispheres in the EC, the CT, and the CPu brain regions. The changes in the MK and K⊥ values showed a parabolic relationship with ages in all the brain regions. Conclusion No laterality in the MK and K⊥ values was observed for the EC, CT, or CPu regions of the rat brain. Significant changes in MK and K⊥ values were both observed among different age groups, thus suggesting diffusion kurtosis imaging as an efficient tool for studying brain aging in rats. No laterality in the MK and K⊥ values was observed for the EC, CT, or CPu regions of the rat brain. Significant changes in MK and K⊥ values were both observed among different age groups, thus suggesting diffusion kurtosis imaging as an efficient tool for studying brain aging in rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|