Efficacy of a monoclonal antibody (MoAb 60.3) in reducing myocardial injury resulting from ischemia/reperfusion in the ferret
| Autor: | Grove Ri, Allen W. Gomoll, Lekich Rf |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Pathology medicine.medical_specialty Time Factors medicine.drug_class Heart Ventricles Ischemia Apparent oxygen utilisation Hemodynamics Coronary Disease Myocardial Reperfusion Injury Monoclonal antibody Internal medicine Occlusion medicine Carnivora Animals Pharmacology biology business.industry Fissipedia Ferrets Antibodies Monoclonal Heart Organ Size medicine.disease biology.organism_classification biology.protein Cardiology Antibody Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of cardiovascular pharmacology. 17(6) |
| ISSN: | 0160-2446 |
| Popis: | The myocardial salvage efficacy of a monoclonal antibody (MoAb 60.3) directed at the CDw 18 membrane antigen complex essential for normal neutrophil function was evaluated in a ferret occlusion/reperfusion model. When infused i.v. over a 10-min interval beginning at the 45th minute of a 90-min occlusion at a fixed dose of 2 mg/kg, the antibody afforded 33 and 45% reductions in infarct size following reperfusion intervals of 6 and 24 h, respectively. Administration of that same dose via the left atrium over 1 h beginning at the 75th minute of occlusion and continuing until the 45th minute of reflow resulted in only a 14% reduction in infarct size. If MoAb 60.3 administration was withheld until the 5th-15th minute of reperfusion, the mean levels of salvage were 19 and 8%, respectively, following 6- and 24-h periods of reflow. Time-course hemodynamic data indicated that the monoclonal antibody caused no alterations in oxygen utilization that might be responsible for the levels of salvage observed. |
| Databáze: | OpenAIRE |
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