High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: a randomized, controlled pilot trial
| Autor: | William C. Dodson, Allen R. Kunselman, Julie Shah, Mary E. J. Lott, Richard S. Legro, Christy Stetter, Nazia Raja-Khan |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Vitamin
Adult Blood Glucose medicine.medical_specialty Time Factors Adolescent medicine.medical_treatment Blood Pressure Pilot Projects Placebo Article chemistry.chemical_compound Young Adult Insulin resistance Double-Blind Method Internal medicine medicine Vitamin D and neurology Humans Insulin Cholecalciferol Glucose tolerance test Academic Medical Centers medicine.diagnostic_test business.industry Quantitative insulin sensitivity check index Obstetrics and Gynecology Vitamins Glucose Tolerance Test Middle Aged Pennsylvania medicine.disease Polycystic ovary Endocrinology Treatment Outcome Reproductive Medicine chemistry Dietary Supplements Female Insulin Resistance business Biomarkers Polycystic Ovary Syndrome |
| Zdroj: | Fertility and sterility. 101(6) |
| ISSN: | 1556-5653 |
| Popis: | Objective To determine the effects of high-dose vitamin D on insulin sensitivity in polycystic ovary syndrome (PCOS). Design Randomized, placebo-controlled trial. Setting Academic medical center. Patient(s) Twenty-eight women with PCOS. Intervention(s) Vitamin D3, 12,000 IU, or placebo daily for 12 weeks. Main Outcome Measure(s) The primary outcome was quantitative insulin sensitivity check index. Secondary outcomes included glucose and insulin levels during a 75-g oral glucose tolerance test and blood pressure. Result(s) Twenty-two women completed the study. Compared with placebo, vitamin D significantly increased 25-hydroxyvitamin D (mean [95% confidence interval] in vitamin D group 20.1 [15.7 to 24.5] ng/mL at baseline and 65.7 [52.3 to 79.2] ng/mL at 12 weeks; placebo 22.5 [18.1 to 26.8] ng/mL at baseline and 23.8 [10.4 to 37.2] ng/mL at 12 weeks). There were no significant differences in quantitative insulin sensitivity check index and other measures of insulin sensitivity; however, we observed trends toward lower 2-hour insulin and lower 2-hour glucose. We also observed a protective effect of vitamin D on blood pressure. Conclusion(s) In women with PCOS, insulin sensitivity was unchanged with high-dose vitamin D, but there was a trend toward decreased 2-hour insulin and a protective effect on blood pressure. Clinical Trial Registration Number NCT00907153. |
| Databáze: | OpenAIRE |
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