Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy
| Autor: | Valery V. Tuchin, B. N. Khlebtsov, Irina L. Maksimova, Leyla V. Suleymanova, Garif G. Akchurin, Nikolay G. Khlebtsov, Georgy S. Terentyuk, Galina N. Maslyakova |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Hyperthermia
Materials science Biomedical Engineering Nanoparticle Nanotechnology 02 engineering and technology 01 natural sciences Models Biological law.invention 010309 optics Biomaterials In vivo law 0103 physical sciences medicine Humans Computer Simulation Irradiation Lasers Hyperthermia Induced Photothermal therapy Phototherapy 021001 nanoscience & nanotechnology Laser medicine.disease Atomic and Molecular Physics and Optics 3. Good health Electronic Optical and Magnetic Materials Colloidal gold Nanoparticles Gold 0210 nano-technology Preclinical imaging Biomedical engineering |
| Zdroj: | Journal of biomedical optics. 14(2) |
| ISSN: | 1083-3668 |
| Popis: | We describe an application of plasmonic silica/gold nanoshells to produce a controllable laser hyperthermia in tissues with the aim of the enhancement of cancer photothermal therapy. Laser irradiation parameters are optimized on the basis of preliminary experimental studies using a test-tube phantom and laboratory rats. Temperature distributions on the animal skin surface at hypodermic and intramuscular injection of gold nanoparticle suspensions and affectations by the laser radiation are measured in vivo with a thermal imaging system. The results of temperature measurements are compared with tissue histology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|