Urinary 3'5' cyclic AMP. Diagnostic test in pseudohypoparathyroidism
| Autor: | W J Tze, G I Drummond, J Saunders |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty Kidney Cortex Urinary system chemistry.chemical_element Parathyroid hormone Calcium Phosphorus metabolism Internal medicine Cyclic AMP Humans Medicine Infusions Parenteral Magnesium Child Normal control Pseudohypoparathyroidism business.industry Diagnostic test Phosphorus medicine.disease Adenosine Endocrinology chemistry Parathyroid Hormone Child Preschool Pediatrics Perinatology and Child Health Female business Research Article medicine.drug |
| Zdroj: | Archives of Disease in Childhood. 50:656-658 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.50.8.656 |
| Popis: | Measurement of urinary cyclic AMP (adenosine 3'5'-cyclic phosphate) and examination of calcium and phosphorus metabolism was carried out in two children with pseudohypoparathyroidism. In both patients infusion of parathyroid hormone failed to elicit any change in urinary cyclic AMP, while a dose-dependent increase in urinary cyclic AMP occurred in a normal control. The findings agree with concept of unresponsiveness of renal cortical tissue to parathyroid hormone in pseudohypoparathyroidism and provide further evidence that measurement of urinary cyclic AMP during parathyroid hormone infusion may be the method of choice in the diagnosis of this disease. |
| Databáze: | OpenAIRE |
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