The Outcome of Patients with Nephrogenic Systemic Fibrosis after Successful Kidney Transplantation
| Autor: | N. Leung, A. Shaikh, F.G. Cosio, M.D. Griffin, S.C. Textor, J.M. Gloor, T.R. Schwab, T.S. Larson, P.G. Dean, M. Prieto, S.L. Nyberg, M.D. Stegall, C.U. Lee, M.R. Pittelkow |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Urology Renal function Nephrogenic Fibrosing Dermopathy chemistry.chemical_compound medicine Humans Immunology and Allergy Pharmacology (medical) Kidney transplantation Dialysis Aged Retrospective Studies Transplantation Creatinine Kidney Thymoglobulin business.industry Graft Survival Middle Aged medicine.disease Kidney Transplantation Surgery Treatment Outcome medicine.anatomical_structure chemistry Nephrogenic systemic fibrosis Disease Progression Female business Follow-Up Studies Glomerular Filtration Rate Kidney disease |
| Zdroj: | American Journal of Transplantation. 10:558-562 |
| ISSN: | 1600-6135 |
| Popis: | Nephrogenic systemic fibrosis (NSF) is a debilitating disease in patients with severely diminished kidney function. Currently, no standard treatment exists but improvement has been reported after restoration of kidney function. We retrospectively studied 17 NSF patients with and without successful kidney transplantation (KTx) to evaluate the effects of KTx on NSF. Nine of the 11 KTx developed NSF pretransplant whereas two developed NSF immediately after KTx with delayed graft function. Two of the six dialysis patients had previous failed kidney transplants. Age and sex were well matched. All but one patient was dialysis dependent at the time of NSF. Median follow-up was 35 months for KTx patients and 9 months for dialysis patients. Kidney transplants achieved adequate renal function with median serum creatinine of 1.4 (0.9-2.8) mg/dL and a glomerular filtration rate of 42 (19-60) mL/min/1.73 m(2). NSF improved in 54.6% of the transplanted patients and 50% of the nontransplanted patients (p = 0.86). Two KTx patients had complete resolution of their symptoms whereas four had partial improvement. Improvement in the dialysis patients was all partial. Successful KTx did not insure improvement in NSF and in fact appeared to have no significant benefit over dialysis. |
| Databáze: | OpenAIRE |
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