Micronutrients in support to the one carbon cycle for the modulation of blood fasting homocysteine in PCOS women
| Autor: | Alberto Falorni, A. Costantino, Alessandro Favilli, N. Schiuma, Vittorio Bini, Maria Chiara Aglietti, Sandro Gerli, Maurizio Dattilo, M. Renga, T. Bartolotti |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Infertility medicine.medical_specialty Homocysteine Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Disease One carbon cycle Carbon Cycle Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Sex hormone-binding globulin Internal medicine PCOS medicine Humans Micronutrients Prospective Studies Young adult Prospective cohort study Testosterone 030219 obstetrics & reproductive medicine biology business.industry Fasting Micronutrient medicine.disease chemistry biology.protein Original Article Female business Biomarkers Follow-Up Studies Polycystic Ovary Syndrome |
| Zdroj: | Journal of Endocrinological Investigation |
| ISSN: | 1720-8386 |
| DOI: | 10.1007/s40618-019-01163-x |
| Popis: | Purpose Fasting blood homocysteine is increased in PCOS women and is involved in several of its co-morbidities including cardiovascular disease and infertility. Corrective interventions based on the administration of supra-physiologic doses of folic acid work to a low extent. We aimed to test an alternative approach. Methods This was a prospective, randomized, parallel group, open label, controlled versus no treatment clinical study. PCOS women aged > 18, free from systemic diseases and from pharmacological treatments were randomized with a 2:1 ratio for treatment with activated micronutrients in support to the carbon cycle (Impryl, Parthenogen, Switzerland—n = 22) or no treatment (n = 10) and followed-up for 3 months. Fasting blood homocysteine, AMH, testosterone, SHBGs, and the resulting FTI were tested before and at the end of the follow-up. Results The mean baseline fasting blood homocysteine was above the normal limit of 12 μMol/L and inversely correlated with SHBG. AMH was also increased, whereas testosterone, SHBG, and FTI were within the normal limit. The treatment achieved a significant reduction of homocysteine, that did not change in the control group, independently of the starting value. The treatment also caused an increase of AMH and a decrease of SHBGs only in the subgroup with a normal homocysteine at baseline. Conclusions In PCOS ladies, blood homocysteine is increased and inversely correlated with the SHBGs. Physiologic amounts of activated micronutrients in support to the carbon cycle achieve a reduction virtually in all exposed patients. Whether this is of clinical benefit remains to be established. |
| Databáze: | OpenAIRE |
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