Total Synthesis of (−)-Okilactomycin
| Autor: | Amos B. Smith, Todd Bosanac, Kallol Basu |
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| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Journal of the American Chemical Society. 129:14872-14874 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja077569l |
| Popis: | A highly convergent synthesis of (-)-okilactomycin is described. Key reactions of this synthesis include a strategy-level diastereoselective oxy-Cope rearrangement/oxidation sequence, a Petasis-Ferrier union/rearrangement tactic, and an efficient RCM reaction to construct the 13-membered macrocyclic ring. |
| Databáze: | OpenAIRE |
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