Glycosyl-transferase catalyzed assemblage of sialyl-lewis x -saccharopeptides
| ISSN: | 0968-0896 |
|---|---|
| DOI: | 10.1016/s0968-0896(98)00107-2 |
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b2f0894233693228d5d95eb6cee337 https://doi.org/10.1016/s0968-0896(98)00107-2 |
| Rights: | CLOSED |
| Přírůstkové číslo: | edsair.doi.dedup.....d2b2f0894233693228d5d95eb6cee337 |
| Autor: | Gabi Baisch, Reinhold Öhrlein |
| Rok vydání: | 1998 |
| Předmět: |
Glycosylation
Magnetic Resonance Spectroscopy beta-Galactoside alpha-2 3-Sialyltransferase Stereochemistry Clinical Biochemistry Oligosaccharides Pharmaceutical Science Biochemistry Sugar acids Fucose Substrate Specificity Structure-Activity Relationship chemistry.chemical_compound Polysaccharides N-Acetyllactosamine Synthase Drug Discovery Glycosyltransferase Sialyl Lewis X Antigen Molecular Biology chemistry.chemical_classification biology Organic Chemistry Fucosyltransferases Sialyltransferases Sialic acid carbohydrates (lipids) Enzyme Sialyl-Lewis X chemistry Galactose biology.protein Molecular Medicine Peptides |
| Zdroj: | Bioorganic & Medicinal Chemistry. 6:1673-1682 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/s0968-0896(98)00107-2 |
| Popis: | A series of glycohexopyranuronic acids are coupled to glucosamines to give 'disaccharides' which have the natural N-acetyl group of the glcNAc-moiety replaced by various sugar acids (-->saccharopeptides). These saccharopeptides are surprisingly good substrates for beta(1-4)galactosyl-transferase, alpha(2-3)sialyl-transferase, and fucosyl-transferase VI. The enzymes transfer successively galactose, sialic acid, and fucose from the corresponding donors onto these acceptor substrates--despite the far reaching alterations--regio- and stereospecifically in the expected manner to yield a new class of compounds, the sialyl-Lewis(x)-saccharopeptides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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