Association between hepatic fat and subclinical vascular disease burden in the general population
| Autor: | Ulf Schminke, Jens-Peter Kühn, Henry Völzke, Jana Nano, Simon Hohenester, Susanne Rospleszcz, Robin Bülow, Roberto Lorbeer, Barbara Thorand, Fabian Bamberg, Corinna Storz, Annette Peters, Xinting Cai, Michael Roden, Birger Mensel, Ali A. Aghdassi, Christopher L. Schlett, Wolfgang Rathmann |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Epidemiology Population cardiovascular complications RC799-869 Disease Carotid Intima-Media Thickness Gastroenterology Disease Screening Internal medicine medicine Humans magnetic resonance imaging Vascular Diseases Cardiovascular Complications Fatty Liver Magnetic Resonance Imaging education Adiposity fatty liver Subclinical infection education.field_of_study business.industry Vascular disease Fatty liver Diseases of the digestive system. Gastroenterology medicine.disease Cross-Sectional Studies Liver Study of Health in Pomerania business Body mass index |
| Zdroj: | BMJ Open Gastroenterology, Vol 8, Iss 1 (2021) BMJ Open Gastroenterol. 8:e000709 (2021) BMJ Open Gastroenterology |
| ISSN: | 2054-4774 |
| Popis: | ObjectiveIt is still controversial if increased hepatic fat independently contributes to cardiovascular risk. We aimed to assess the association between hepatic fat quantified by MRI and various subclinical vascular disease parameters.DesignWe included two cross-sectional investigations embedded in two independent population-based studies (Study of Health in Pomerania (SHIP): n=1341; Cooperative Health Research in the Region of Augsburg (KORA): n=386). The participants underwent a whole-body MRI examination. Hepatic fat content was quantified by proton-density fat fraction (PDFF). Aortic diameters in both studies and carotid plaque-related parameters in KORA were measured with MRI. In SHIP, carotid intima-media thickness (cIMT) and plaque were assessed by ultrasound. We used (ordered) logistic or linear regression to assess associations between hepatic fat and subclinical vascular disease.ResultsThe prevalence of fatty liver disease (FLD) (PDFF >5.6%) was 35% in SHIP and 43% in KORA. In SHIP, hepatic fat was positively associated with ascending (β, 95% CI 0.06 (0.04 to 0.08)), descending (0.05 (0.04 to 0.07)) and infrarenal (0.02 (0.01 to 0.03)) aortic diameters, as well as with higher odds of plaque presence (OR, 95% CI 1.22 (1.05 to 1.42)) and greater cIMT (β, 95% CI 0.01 (0.004 to 0.02)) in the age-adjusted and sex-adjusted model. However, further adjustment for additional cardiometabolic risk factors, particularly body mass index, attenuated these associations. In KORA, no significant associations were found.ConclusionsThe relation between hepatic fat and subclinical vascular disease was not independent of overall adiposity. Given the close relation of FLD with cardiometabolic risk factors, people with FLD should still be prioritised for cardiovascular disease screening. |
| Databáze: | OpenAIRE |
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