Extracellular RNAs: A new awareness of old perspectives
| Autor: | Noah Sadik, Lilian Cruz, Zhiyun Wei, Marike L. D. Broekman, Thomas S van Solinge, Bence György, Leonora Balaj, Alessandra Gurtner, Rodosthenis S. Rodosthenous, Ane Miren Salvador-Garicano, Sophie A. Dusoswa, Olivia Ziegler |
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| Přispěvatelé: | Molecular cell biology and Immunology, Neurosurgery |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
RNA Computational biology Biology Non-coding RNA Extracellular vesicles Microvesicles Article 03 medical and health sciences Extracellular Vesicles MicroRNAs 030104 developmental biology Extracellular Animals Humans RNA Messenger Biomarker discovery Extracellular Space Biogenesis Extracellular RNA |
| Zdroj: | Methods in Molecular Biology, 1740, 1-15 Methods in Molecular Biology ISBN: 9781493976515 Sadik, N, Cruz, L, Gurtner, A, Rodosthenous, R S, Dusoswa, S A, Ziegler, O, van Solinge, T S, Wei, Z, Salvador-Garicano, A M, Gyorgy, B, Broekman, M & Balaj, L 2018, Extracellular RNAs: A new awareness of old perspectives . in Methods in Molecular Biology . vol. 1740, Methods in Molecular Biology, Humana Press Inc., pp. 1-15 . https://doi.org/10.1007/978-1-4939-7652-2_1 |
| ISSN: | 1064-3745 |
| DOI: | 10.1007/978-1-4939-7652-2_1 |
| Popis: | Extracellular RNA (exRNA) has recently expanded as a highly important area of study in biomarker discovery and cancer therapeutics. exRNA consists of diverse RNA subpopulations that are normally protected from degradation by incorporation into membranous vesicles or by lipid/protein association. They are found circulating in biofluids, and have proven highly promising for minimally invasive diagnostic and prognostic purposes, particularly in oncology. Recent work has made progress in our understanding of exRNAs—from their biogenesis, compartmentalization, and vesicle packaging to their various applications as biomarkers and therapeutics, as well as the new challenges that arise in isolation and purification for accurate and reproducible analysis. Here we review the most recent advancements in exRNA research. |
| Databáze: | OpenAIRE |
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