pHLA3D: Updating the database of predicted three-dimensional structures of HLA with HLA-DR, HLA-DQ and HLA-DP molecules

Autor:	Antonio Gilberto Borges Coelho, Jhonatan Matheus Sousa Costa, Rafael Melo Santos de Serpa Brandão, Ester Miranda Pereira, Ricardo Martins Ramos, Luiz Claudio Demes da Mata Sousa, Mário Sérgio Coelho Marroquim, Antonio Vanildo de Sousa Lima, Semiramis Jamil Hadad do Monte, Adalberto Socorro da Silva, Deylane Menezes Teles e Oliveira, Francisco das Chagas Alves Lima
Rok vydání:	2020
Předmět:	0301 basic medicine Hla class ii HLA-DP Antigens Computer science Immunology HLA-DP Human leukocyte antigen computer.software_genre 03 medical and health sciences 0302 clinical medicine Hla molecules HLA-DQ Antigens HLA-DQ HLA-DR Immunology and Allergy Humans Homology modeling Databases Protein Database Sequence Homology Amino Acid Computational Biology MODELLER General Medicine HLA-DR Antigens Protein Structure Tertiary 030104 developmental biology computer Software 030215 immunology
Zdroj:	Human immunology. 82(1)
ISSN:	1879-1166
Popis:	To improve the availability of three-dimensional (3D) structures of HLA molecules, we created the pHLA3D database. In its first version, we modeled and published 106 3D structures of HLA class I molecules from the HLA-A, HLA-B, and HLA-C loci. This paper presents an update of this database, providing more 127 3D structures of HLA class II molecules (41 DR, 42 DQ, and 44 DP), predicted via homology modeling with MODELLER and SWISS-MODEL. These new 3D structures of HLA class II molecules are now freely available at pHLA3D (www.phla3d.com.br) for immunologists and other researchers working with HLA molecules.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2aec0482135ca6a83a2405e07770854 https://pubmed.ncbi.nlm.nih.gov/33129577 Zobrazit plný text záznamu Full Text from ScienceDirect