Subchronic inhalation toxicity of 1,3,5-trichlorobenzene
| Autor: | J. S. Johnson, Daniel P. Sasmore, C. Mitoma, Charles A. Tyson |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Porphyrins Health Toxicology and Mutagenesis Physiology Trichlorobenzene Toxicology Chlorobenzenes Eating RED MATERIAL medicine Animals Nasal passages Pharmacology Chemical Health and Safety Inhalation Chemistry Body Weight Public Health Environmental and Occupational Health General Medicine Organ Size Hyperplasia medicine.disease Squamous metaplasia Rats Liver Toxicity Respiratory epithelium Female medicine.drug |
| Zdroj: | Drug and chemical toxicology. 6(3) |
| ISSN: | 0148-0545 |
| Popis: | Male and female rats were exposed to 0, 10, 100 or 1000 mg/m3 of 1,3,5-trichlorobenzene vapors for 6 hours daily, 5 days a week, for up to 13 weeks. After 4 and 13 weeks of exposure, animals were sacrificed and examined for changes in blood, clinical chemistry, internal organs, and tissues resulting from the 1,3,5-trichlorobenzene treatment. No treatment-related effects on the blood and clinical chemistry were evident. The only effects that were considered treatment-related were a squamous metaplasia and hyperplasia in the respiratory epithelium in the nasal passages of high-dose rats and the increased incidence of dried red material on the faces of these rats during exposures compared with other groups. |
| Databáze: | OpenAIRE |
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