Serum Iron and Ferritin Levels Are Correlated with Complement C3
| Autor: | Bicheng Wang, Zhilian Rui, Yeqin Sha, Dongyan Shi, Fengfeng Yan, Xu Han, Chenhong Si, Yinling Li, Shuang Wen, Yuning Zhou, Jingming Hu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Iron Endocrinology Diabetes and Metabolism Clinical Biochemistry 010501 environmental sciences 01 natural sciences Biochemistry Inorganic Chemistry Mice 03 medical and health sciences Immune system Internal medicine medicine Animals 0105 earth and related environmental sciences 0303 health sciences Innate immune system biology medicine.diagnostic_test Chemistry 030302 biochemistry & molecular biology Biochemistry (medical) Complement C4 Complement C3 General Medicine Metabolism Complement system Complement (complexity) Ferritin Endocrinology Ferritins biology.protein Serum iron Homeostasis |
| Zdroj: | Biological Trace Element Research. 199:2482-2488 |
| ISSN: | 1559-0720 0163-4984 |
| Popis: | Iron is one of the most important trace elements in the body, and its homeostasis is essential to the normal function of the immune system. Complement component C3, which is the converging of three main pathways of complement system activation, plays a key role in the innate immunity. However, the relationship between iron homeostasis and complement C3 remains unknown. The aim of our study was to analyze the relationship between serum iron and ferritin level and complement C3 and C4. A total of 590 healthy individuals were recruited in our study. Higher serum complement C3 level (p 104.0 μg/L). Moreover, serum iron level and serum ferritin level were positively correlated with complement C3 (r = 0.133, p = 0.001; r = 0.221, p |
| Databáze: | OpenAIRE |
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