Phenotypic heterogeneity in three cases of lymphoid malignancy with chromosomal translocations in 14q11
| Autor: | M.L. Greenberg, I.D. Dubé |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Lineage (genetic) Lymphoma T-Lymphocytes Chromosomal translocation Biology Translocation Genetic Pathogenesis Antigens Neoplasm Bone Marrow Acute lymphocytic leukemia Genetics medicine Humans Child Molecular Biology Gene Cells Cultured Genetics (clinical) Genetic heterogeneity Cytogenetics medicine.disease Phenotype Child Preschool Karyotyping Female Chromosomes Human 13-15 |
| Zdroj: | Cytogenetic and Genome Research. 41:215-218 |
| ISSN: | 1424-859X 1424-8581 |
| Popis: | Lymphoid malignancies bearing translocations involving the region 14q 11 are thought to have a T-cell phenotype because their pathogenesis is postulated to involve the aberrant juxtaposition of DNA sequences active in T-cell differentiation (T-cell antigen receptor genes) and proto-oncogenes. We present here three lymphoid malignancies with translocations involving 14q11. Although one had a T-cell phenotype, the other two had B-cell lineage phenotypes. Our findings confirm that not all lymphoid malignancies with translocations involving 14q 11 represent T-cell clonal expansions. |
| Databáze: | OpenAIRE |
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