Impaired Natural Killer Cell Activity Associates with Increased Susceptibility to Inflammation Induced by Herpesvirus Infection in Patients with Nickel Hypersensitivity
| Autor: | M. Proietti, A. R. Proietti, F. Mastronardo, E. Roumpedaki, Felice Salsano, Simonetta Pisarri, C. Francia, A. Giovannetti, Marina Pierdominici |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Allergy
Natural Killer Cell Activity Immunology lcsh:R Patch test lcsh:Medicine Inflammation Biology medicine.disease medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Allergen 030220 oncology & carcinogenesis Herpesvirus infection medicine Immunology and Allergy In patient medicine.symptom Allergic contact dermatitis 030215 immunology |
| Zdroj: | European Journal of Inflammation, Vol 3 (2005) |
| Popis: | Nickel (Ni) is one of the most common causes of allergic contact dermatitis (ACD) and the number one allergen in the frequency of positive patch test reactions. The cellular basis of ACD is the lack of specialized T cells with regulatory function allowing for the expansion of Ni[Formula: see text] specific cytotoxic CD8+ T cells. However, Ni also exerts a number of not yet fully understood activities on cells belonging to the immune system. To this regard, an immunosuppressive activity of Ni on natural killer (NK) cells has been repeatedly suggested both in animal models and humans. Here we demonstrate that NK activity of Ni[Formula: see text] intolerant patients was significantly lower than observed in controls. Moreover, the addition of Ni[Formula: see text] sulphate to cultures of peripheral blood lymphocytes (PBL) obtained by Ni[Formula: see text] allergic patients, further depressed the NK cell activity. Finally, according to the key role exerted by NK cells in containing viral infections, we found an increased frequency of Herpesvirus 1 (HSV-1) recurrence among patients with Ni[Formula: see text] allergy. In conclusion, our results indicate that Ni[Formula: see text] allergic patients may present reduced NK cell response, this resulting in turn in increased susceptibility to viral infections. Patch testing should be considered in individuals affected by unexplained recurrences of HSV-1 infection. |
| Databáze: | OpenAIRE |
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