Fundamentals of fetal toxicity relevant to sevoflurane exposures during pregnancy
| Autor: | Dongdong Chai, Yanyong Cheng, Hong Jiang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Offspring
Bioinformatics Sevoflurane 03 medical and health sciences Fetus 0302 clinical medicine Developmental Neuroscience Pregnancy Fetal intervention Humans Medicine 030304 developmental biology 0303 health sciences business.industry Neurotoxicity medicine.disease Pregnancy Complications Prenatal Exposure Delayed Effects Anesthetics Inhalation Anesthetic Toxicity Female business 030217 neurology & neurosurgery Developmental Biology medicine.drug |
| Zdroj: | International Journal of Developmental Neuroscience. 72:31-35 |
| ISSN: | 1873-474X 0736-5748 |
| DOI: | 10.1016/j.ijdevneu.2018.11.001 |
| Popis: | Over the last three decades, advances in medical and surgical techniques have proven life saving and life-improving for young children. Consequently, early and repeated exposure to general anesthetics in childhood has increased. However, accumulating evidence suggests that general anesthetics may be neurotoxic in children. Of particular concern is the neurotoxicity fetuses may suffer from maternal exposure to sevoflurane during surgeries and fetal intervention procedures performed during the second trimester, as this can cause neurodevelopmental impairment in offspring. In this review we demonstrate that the pathology associated with fetal toxicity resulting from exposure to sevoflurane during pregnancy involves oxidative stress, neuroinflammation, neuroapoptosis, and alteration of synaptic properties. The mechanisms remain to be elucidated, but may include increased tau protein phosphorylation and abnormal methylation. These findings highlight the need for a global and comprehensive understanding of the potential neurotoxicity of anesthetic exposure in fetuses and its long-term effects. |
| Databáze: | OpenAIRE |
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