Congenital toxoplasmosis in the United States: clinical and serologic findings in infants born to mothers treated during pregnancy
| Autor: | Cindy Press, Tudor Olariu, Jose G. Montoya, Kjerstie Olson, Jeanne Talucod |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Pediatrics Clinical findings Antibodies Protozoan Toxoplasmosis Congenital Serology 0302 clinical medicine Pregnancy 030212 general & internal medicine Congenital toxoplasmosis 030219 obstetrics & reproductive medicine Infectious Diseases Cohort Lower prevalence Female Infants Hydrocephalus medicine.medical_specialty Short Note Veterinary (miscellaneous) Mothers Serologic findings Enzyme-Linked Immunosorbent Assay Biology Sensitivity and Specificity lcsh:Infectious and parasitic diseases 03 medical and health sciences medicine Humans lcsh:RC109-216 Serologic Tests Retrospective Studies Clinical Laboratory Techniques Infant Newborn Infant Retrospective cohort study medicine.disease Infectious Disease Transmission Vertical United States Toxoplasmosis Immunoglobulin M Laboratory diagnosis Immunoglobulin G Pregnancy Complications Parasitic Insect Science Animal Science and Zoology Parasitology |
| Zdroj: | Parasite Parasite, Vol 26, p 13 (2019) |
| ISSN: | 1776-1042 |
| Popis: | We assessed clinical and serologic findings in 25 infants with congenital toxoplasmosis born to mothers treated during pregnancy in the United States. Results indicate a lower prevalence of eye findings and hydrocephalus in the group of infants born to treated mothers (62.5% and 38.5%, respectively) compared to results on the same pathologies reported in our previous cohort of infants born to untreated mothers (92.2% and 67.7%, respectively). The sensitivity of the IgM ISAGA and IgA ELISA in the present study were lower (44% and 60%, respectively) compared to sensitivity of these methods in our previously studied group of infants born to untreated mothers (86.6% and 76.5%, respectively). These findings provide further evidence that anti-parasitic treatment if administered during pregnancy can contribute to better clinical outcomes, even in countries where systematic screening and treatment have not been routinely implemented. |
| Databáze: | OpenAIRE |
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