Solvent-Free Fabrication of Self-Regenerating Antibacterial Surfaces Resisting Biofilm Formation
| Autor: | Cuicui Su, Yumin Ye, Haofeng Qiu, Yabin Zhu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Staphylococcus aureus
Materials science Fabrication Methacrylic anhydride 02 engineering and technology Chemical vapor deposition Microbial Sensitivity Tests engineering.material Urinary Catheters 010402 general chemistry 01 natural sciences chemistry.chemical_compound Adsorption Coating Coated Materials Biocompatible Polymethacrylic Acids Escherichia coli General Materials Science biology Biofilm 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences Anti-Bacterial Agents chemistry Chemical engineering Biofilms engineering Polystyrenes 0210 nano-technology Layer (electronics) Bacteria Dimethylamines |
| Zdroj: | ACS applied materialsinterfaces. 13(8) |
| ISSN: | 1944-8252 |
| Popis: | Biofilm formation on indwelling medical devices is a major cause of hospital-acquired infections. Monofunctional antibacterial surfaces have been developed to resist the formation of biofilms by killing bacteria on contact, but the adsorption of killed bacterial cells and debris gradually undermines the function of these surfaces. Here, we report a facile approach to produce an antibacterial surface that can regenerate its function after contamination. The self-regenerating surface was achieved by sequential deposition of alternating antibacterial and biodegradable layers of coating using a solvent-free initiated chemical vapor deposition method. As the top antibacterial layer gradually loses its killing ability due to the accumulation of debris, the underlying biodegradable layer degrades, shedding off the top surface layers and exposing another fresh antibacterial surface. Urinary catheters coated with monofunctional and self-regenerating antibacterial coatings both showed more than 99% bacterial killing ability at the initial antibacterial test, but the monofunctional surface lost its killing ability after continued exposure to concentrated bacterial solution, whereas the self-regenerating surfaces regained strong bacterial killing ability after prolonged exposure. Employing poly(methacrylic anhydride) and its copolymers with varied composition as the degrading layer, the degradation kinetics can be well-tailored and the self-regeneration duration spanned from minutes to days. The designed self-regenerating antibacterial surfaces could provide an effective approach to resist biofilm formation and extend the service life of indwelling medical devices. |
| Databáze: | OpenAIRE |
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