In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)
| Autor: | Eva-Maria Pferschy-Wenzig, Vivian Leliebre-Lara, Lianet Monzote Fidalgo, Clara Nogueiras Lima, Rudolf Bauer, Olaf Kunert |
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| Rok vydání: | 2016 |
| Předmět: |
0106 biological sciences
Cell Survival Trametes versicolor Pharmaceutical Science Trametenolic acid 01 natural sciences Lanostane Analytical Chemistry lcsh:QD241-441 Mice chemistry.chemical_compound lcsh:Organic chemistry Trametes 010608 biotechnology Drug Discovery Animals antileishmanial activity Fruiting Bodies Fungal Physical and Theoretical Chemistry Amastigote IC50 Trypanocidal agent Leishmania Molecular Structure biology 010405 organic chemistry Communication Organic Chemistry trametenolic acid B biology.organism_classification Trypanocidal Agents 0104 chemical sciences Sterols chemistry Biochemistry Chemistry (miscellaneous) Macrophages Peritoneal Molecular Medicine |
| Zdroj: | Molecules, Vol 21, Iss 8, p 1045 (2016) Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules21081045 |
| Popis: | Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden). The activity of the isolated sterols was evaluated against promastigotes and amastigotes of Leishmania amazonensis Lainson and Shaw, 1972. The lanostane, compound (3), showed the best inhibitory response (IC50 promastigotes 2.9 ± 0.1 μM and IC50 amastigotes 1.6 ± 0.1 μM). This effect was 25-fold higher compared with its cytotoxic effect on peritoneal macrophages from BALB/c mice. Therefore, trametenolic acid could be regarded as a promising lead for the synthesis of compounds with antileishmanial activity. |
| Databáze: | OpenAIRE |
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