Antihypertensive therapy improves insulin resistance and serum levels of interleukin-6 and −10 in spontaneously hypertensive rats with steatohepatitis
| Autor: | Shiho Arima, Hiroki Taguchi, Masatsugu Numata, Hirohito Tsubouchi, Rie Ibusuki, Akio Ido, Shinichi Hashimoto, Hitoshi Setoyama, Fumisato Sasaki, Yuichiro Nasu, Masaya Kozono, Kohei Oda, Hirofumi Uto, Shuji Kanmura |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine Cancer Research medicine.medical_specialty medicine.medical_treatment Antigens Differentiation Myelomonocytic Blood Pressure Biochemistry 03 medical and health sciences 0302 clinical medicine Insulin resistance Antigens CD Non-alcoholic Fatty Liver Disease T-Lymphocyte Subsets Rats Inbred SHR Internal medicine Genetics Animals Insulin Medicine Amlodipine Molecular Biology Antihypertensive Agents Chemokine CCL2 Interleukin-6 business.industry Interleukin Hydralazine medicine.disease Diet Interleukin-10 Rats Disease Models Animal 030104 developmental biology Blood pressure Endocrinology Oncology Hypertension Molecular Medicine 030211 gastroenterology & hepatology Insulin Resistance Steatohepatitis Metabolic syndrome business Biomarkers medicine.drug |
| Zdroj: | Molecular Medicine Reports. 14:5385-5394 |
| ISSN: | 1791-3004 1791-2997 |
| Popis: | Metabolic syndrome based on insulin resistance (IR) and hypertension is a risk factor for advanced liver disease and cardiovascular disease in patients with nonalcoholic steatohepatitis (NASH). The present study investigated the effects of severe hypertension induced by a high‑salt (HS) diet and antihypertensive therapy on the pathophysiological condition of spontaneously hypertensive rats (SHRs) with steatohepatitis. Steatohepatitis was induced using a choline-deficient, L-amino acid-defined diet (CDAA). Male SHRs (7‑week‑old) were randomly divided into five groups: Those receiving 6 weeks of standard chow with a normal salt concentration, followed by an additional 8 weeks of standard chow or CDAA with a normal salt concentration (control and CDAA groups, respectively); and those receiving 6 weeks of standard chow with HS, followed by CDAA with HS for an additional 8 weeks, with or without the antihypertensive agents, amlodipine (Aml) or hydralazine. In the CDAA and CDAA+HS groups, blood pressure was significantly correlated with serum levels of insulin, fasting blood glucose and homeostasis model assessment (HOMA)‑IR. Antihypertensive therapy ameliorated the elevated glucose, insulin and HOMA‑IR. Furthermore, the increased levels of serum interleukin (IL)‑6 following the CDAA+HS diet were attenuated by antihypertensive therapy. The serum levels of IL‑10 were increased by antihypertensive therapy, and the decrease in the proportion of splenic CD4+CD25+forkhead box P3+ T cells observed following the CDAA+HS diet tended to be restored by Aml. In conclusion, antihypertensive therapy improved glucose metabolism and imbalances in cytokine expression in the rat model of hypertension with steatohepatitis, suggesting that antihypertensive therapy acting through immunological factors may be beneficial for patients with metabolic syndrome-associated NASH. |
| Databáze: | OpenAIRE |
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