The anti-inflammatory action of fermented soybean products in kidney of high-fat-fed rats
| Autor: | Sun-Hwa Kwon, Hae Young Chung, Byung Pal Yu, Nam Deuk Kim, Jee H. Jung, Kun-Young Park, Jehun Choi |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.drug_class Anti-Inflammatory Agents Medicine (miscellaneous) Adipose tissue Inflammation Pharmacology Kidney Anti-inflammatory Antioxidants Rats Sprague-Dawley chemistry.chemical_compound Lipid oxidation medicine Animals Cell adhesion Nutrition and Dietetics biology Plant Extracts NF-kappa B Isoflavones Dietary Fats Rats Nitric oxide synthase Oxidative Stress medicine.anatomical_structure Biochemistry chemistry Fermentation Seeds biology.protein Soybeans medicine.symptom Inflammation Mediators Oxidation-Reduction Phytotherapy |
| Zdroj: | Journal of medicinal food. 14(3) |
| ISSN: | 1557-7600 |
| Popis: | Soybean has many compounds with a variety of biological properties that potentially benefit human health; among them, isoflavones have inhibitory effects on lipid oxidation in adipose tissue. In this study, we examined two Korean traditional fermented soybean products--doenjang (DNJ) and cheonggukjang (CGJ)--for their ability to suppress redox-sensitive nuclear factor κB (NF-κB) activation in the kidney of rats fed a high-fat diet. Sprague-Dawley rats, 4 weeks old, were fed soybean, DNJ, or CGJ (1 g/kg/day) with a 20% fat diet for 6 weeks. Body weight and food intake were carefully monitored. NF-κB-related activities of genes for inflammatory proteins, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and vascular cell adhesion molecule-1 (VCAM-1), were determined. The soybean products exhibited antioxidative action by maintaining redox regulation, suppressing NF-κB activation, and modulating the expression of genes for NF-κB-induced inflammatory proteins such as COX-2, iNOS, and VCAM-1. Based on these results, we conclude that Korean traditional soybean fermented products, especially CGJ, suppress the generation of reactive species, NF-κB activity, and NF-κB-related inflammatory genes. |
| Databáze: | OpenAIRE |
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