BRCA1 and VDR gene polymorphisms are associated with prostate cancer risk in Mexican men
| Autor: | Arianna Ventura-Bahena, Rocío Gómez, Gabriela Angélica Martínez-Nava, Ruth Argelia Vázquez-Salas, Luisa Torres-Sánchez, Ana I. Burguete-García |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Genotype Biology Calcitriol receptor 03 medical and health sciences Prostate cancer 0302 clinical medicine Breast cancer Risk Factors Prostate Internal medicine Biomarkers Tumor medicine Humans Genetic Predisposition to Disease Family history Allele Molecular Biology Aged Polymorphism Genetic BRCA1 Protein Prostatic Neoplasms Prognosis medicine.disease Confidence interval 030104 developmental biology medicine.anatomical_structure Case-Control Studies 030220 oncology & carcinogenesis Receptors Calcitriol Follow-Up Studies |
| Zdroj: | Molecular Carcinogenesis. 59:629-639 |
| ISSN: | 1098-2744 0899-1987 |
| DOI: | 10.1002/mc.23187 |
| Popis: | Prostate cancer (PC) is a polygenic disease with broad differences across ethnicities. BRCA1/2 and VDR have exhibited a featured genetic contribution to PC development in European populations. Nonetheless, its contribution in Latino populations specifically among Mexican men, where 70% of PC cases are detected in advanced stages, is still unknown. The contribution of seven polymorphisms in BRCA1/2 and VDR genes to PC susceptibility was evaluated in 370 incident PC cases and 759 age-matched (±5 years) controls belonging to the Mexican population. Based on Gleason score at diagnosis, PC cases were classified as well-differentiated PC (Gleason |
| Databáze: | OpenAIRE |
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