Immunotherapeutic strategies against mucormycosis in haematopoietic stem cell transplantation
| Autor: | Stanislaw Schmidt, Lars Tramsen, Ada Balan, Andreas Schneider, Thomas Lehrnbecher |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
CD4-Positive T-Lymphocytes
Antifungal Agents Neutropenia T cell medicine.medical_treatment Mucormycosis Hematopoietic Stem Cell Transplantation Immunosuppression Dermatology General Medicine Biology medicine.disease Natural killer cell Killer Cells Natural Transplantation Haematopoiesis Infectious Diseases medicine.anatomical_structure Immune system Immunology medicine Humans Stem cell Granulocytes |
| Zdroj: | Mycoses. 57:8-12 |
| ISSN: | 0933-7407 |
| DOI: | 10.1111/myc.12241 |
| Popis: | Summary Mucormycoses remain a serious complication in patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT). In these patients, mortality rates of mucormycosis reach up to 90%, which is due, at least in part, to the severe and prolonged immunosuppression after transplantation. Although prolonged neutropaenia is one of the most important risk factors for mucormycosis, other cell populations, such as CD4+ T cells may also provide critical defence mechanisms against this infection. The management of mucormycosis includes antifungal therapy, surgery and, most importantly, the control of the underlying predisposing conditions, such as the correction of an impaired immune system. Here, we review the current data of granulocytes, antifungal T cells and natural killer cells regarding their activity against mucormycetes and regarding a potential immunotherapeutic approach. It is hoped that further animal studies and clinical trials assessing immunotherapeutic strategies will ultimately improve the poor prognosis of allogeneic HSCT recipients suffering from mucormycosis. |
| Databáze: | OpenAIRE |
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