Sequential Dose-Dense Doxorubicin and Ifosfamide in Advanced Soft-Tissue Sarcoma Patients in an Out-Patient-Basis Schedule

Autor: E. H. Akaishi, Miriam Hatsue Honda Federico, Gilberto de Castro, Olavo Pires de Camargo, Sheila Aparecida Coelho Siqueira, G. F. G. Almeida, I. Snitcovsky, Claudia Regina G. C. M. Oliveira
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Sarcoma
Sarcoma, Vol 2011 (2011)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 1369-1643
1357-714X
Popis: Aims. This phase II study explored activity/safety of front-line dose-dense chemotherapy in high-grade STS (soft tissue sarcoma) patients and tested ezrin as prognostic factor.Patients and Methods. The protocol consisted of three cycles of doxorubicin (DOXO) 30 mg/m2on days 1–3 every 2 weeks, followed by three cycles of ifosfamide (IFO) 2.5 g/m2two hours a day on days 1–5 every 3 weeks, with GCSF support. Ezrin was assessed immunohistochemically.Results. Twenty patients, 13 metastatic and 7 locally advanced, were enrolled. Median age was 39 years (25–60). Median dose intensities were 42 mg/m2/week and 3.6 g/m2/week for DOXO and IFO, respectively. Grade 3/4 toxicities occurred in 18 patients. Response rate was 15% (3 of 20) by RECIST. Patients younger than 45 years with locally advanced disease and synovial histology presented longer survival. A trend towards longer survival was observed among ezrin-positive patients.Conclusions. This dose-dense schedule should not be routinely used due to its high frequency of toxic events; however, a sequential strategy with DOXO and IFO may benefit selected patients and should be further explored with lower doses. The role of ezrin as a prognostic marker should be confirmed in a larger group of patients.
Databáze: OpenAIRE
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