Cytotoxicity and antimicrobial activities of green synthesized silver nanoparticles
| Autor: | V. Narayanan, V. Kaviyarasan, C. Arulvasu, S. Lokina, A. Stephen |
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| Rok vydání: | 2013 |
| Předmět: |
Malus
Silver Metal Nanoparticles Nanotechnology Antineoplastic Agents Microbial Sensitivity Tests Silver nanoparticle Anti-Infective Agents Drug Discovery Spectroscopy Fourier Transform Infrared Humans Fourier transform infrared spectroscopy Surface plasmon resonance Cytotoxicity High-resolution transmission electron microscopy Pharmacology biology Chemistry Organic Chemistry General Medicine Antimicrobial biology.organism_classification Polyphenol MCF-7 Cells Microscopy Electron Scanning Spectrophotometry Ultraviolet Nuclear chemistry |
| Zdroj: | European journal of medicinal chemistry. 76 |
| ISSN: | 1768-3254 |
| Popis: | Bio-inspired silver nanoparticles are synthesized using Malus domestica (apple) extract. Polyphenols present in the apple extract act as a reducing and capping agent to produce the silver nanoparticles. UV–Visible analysis shows the surface plasmon resonance (SPR) absorption at 420 nm. The FTIR analysis was used to identify the functional groups responsible for the bio-reduction of silver ion. The XRD and HRTEM images confirm the formation of silver nanoparticles. The minimal inhibitory concentration (MIC) of silver nanoparticles was recorded against most of the bacteria and fungus. Further, MCF-7 human breast adenocarcinoma cancer cell line was employed to observe the efficacy of cancer cell killing. |
| Databáze: | OpenAIRE |
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