Relationship between oral carcinogenesis and lifestyle habits in Gunma prefecture
| Autor: | Masaru Ogawa, Jun Kurihara, Keisuke Suzuki, Takahiro Yamaguchi, Satoshi Yokoo, Saki Sakaino |
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| Rok vydání: | 2019 |
| Předmět: |
lcsh:RC705-779
Health (social science) business.industry Gunma Public Health Environmental and Occupational Health Medicine (miscellaneous) Cancer lcsh:Diseases of the respiratory system lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease_cause medicine.disease lcsh:RC254-282 stomatognathic diseases Environmental health medicine cancer tobacco and alcohol Carcinogenesis business Lifestyle habits |
| Zdroj: | Tobacco Induced Diseases, Vol 17, Iss 1 (2019) |
| ISSN: | 1617-9625 |
| DOI: | 10.18332/tid/111490 |
| Popis: | Objective Smoking and drinking are risks not only of oral cancer but also of the onset and death of cancer as a whole. In this study, we investigated the effects of smoking and drinking on the onset of oral mucosal disease and examined the relationship with lifestyle diseases (hypertension, dyslipidemia, diabetes) and BMI. Furthermore, the characteristics in Gumma prefecture compared with the whole country were clarified. Methods 1105 subjects who were able to conduct detailed examination among patients who underwent our department from January 2010 to December 2016 were targeted. It was classified into each group diagnosed as oral squamous cell carcinoma (OSCC), High-grade dysplasia and carcinoma in situ(H-dys･CIS), oral lichen planus (OLP) and the control group. The questionnaire and medical records described at the time of the first visit to the reference, oral mucosal disease onset and smoking and drinking, lifestyle-related diseases morbidity, were studied retrospectively the relationship of BMI. Results Age, diabetes mellitus, Brinkman Index was a risk factor for onset in the OSCC group. Observed significant increase in odds ratio of 3.32 in the group which performs both smoking and drinking in men, became more diabetes joins the 12.51 high odds ratio. In addition, the risk increased significantly as the Brinkman Index increased, indicating a correlation between cumulative smoking dose and oral carcinogenesis. Gunma Prefecture, is the latest of statistics is a nationwide first place male smoking rates, may contribute significantly to the oral cancer incidence has been suggested. Conclusions In the group with both smoking and drinking habits, the risk of developing oral cancer significantly increases. Also, the risk is further increased by the factor of diabetes mellitus. There is a dose-response relationship between smoking and the risk of developing oral cancer. In Gunma prefecture, high smoking rate may be involved in the development of oral cancer. |
| Databáze: | OpenAIRE |
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