Evaluation of Alkaloids Isolated from Ruta graveolens as Photosynthesis Inhibitors
| Autor: | Lucas Campos Curcino Vieira, Barbara Sayuri Bellete, Blas Lotina-Hennsen, Olívia Moreira Sampaio, Beatriz King-Díaz, Maria Fátima das Graças Fernandes da Silva, Thiago André Moura Veiga |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Ruta graveolens Chl a fluorescence Pharmaceutical Science Photosynthesis 01 natural sciences Analytical Chemistry lcsh:QD241-441 acridone alkaloids 03 medical and health sciences chemistry.chemical_compound lcsh:Organic chemistry In vivo Drug Discovery Physical and Theoretical Chemistry biology 010405 organic chemistry Chemistry Organic Chemistry photosystem II DCMU Pesticide biology.organism_classification 0104 chemical sciences Acridone 030104 developmental biology Biochemistry Chemistry (miscellaneous) Toxicity Molecular Medicine Phytotoxicity Hill reaction inhibitors |
| Zdroj: | Molecules, Vol 23, Iss 10, p 2693 (2018) Molecules Volume 23 Issue 10 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules23102693 |
| Popis: | Eight alkaloids (1&ndash 8) were isolated from Ruta graveolens, and their herbicide activities were evaluated through in vitro, semivivo, and in vivo assays. The most relevant results were observed for Compounds 5 and 6&ndash 8 at 150 &mu M, which decreased dry biomass by 20% and 23%, respectively. These are significant results since they presented similar values with the positive control, commercial herbicide 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU). Based on the performed assays, Compound 5 (graveoline) is classified as an electron-transport inhibitor during the light phase of photosynthesis, as well as a plant-growth regulator. On the other hand, Compounds 6&ndash 8 inhibited electron and energy transfers, and are also plant-growth inhibitors. These phytotoxic behaviors based on acridone and quinolone alkaloids may serve as a valuable tool in the further development of a new class of herbicides since natural products represent an interesting alternative to replace commercial herbicides, potentially due their low toxicity. |
| Databáze: | OpenAIRE |
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