HLA haplotypes and class II molecular alleles in Argentinian patients with pemphigus vulgaris
| Autor: | Mijail Gruber, Alberto Woscoff, Leonardo Fainboim, Graciela Rodríguez Costa, R. Haas, Roberto Glorio |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotype Argentina Human leukocyte antigen Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Gene Frequency immune system diseases HLA Antigens Immunopathology medicine Genetic predisposition Humans Genetic Predisposition to Disease Allele skin and connective tissue diseases Alleles Aged Gynecology Aged 80 and over business.industry Pemphigus vulgaris Haplotype Histocompatibility Antigens Class II Middle Aged medicine.disease HLA-A Pemphigus Haplotypes 030220 oncology & carcinogenesis Surgery Female business |
| Zdroj: | Journal of cutaneous medicine and surgery. 6(5) |
| ISSN: | 1203-4754 |
| Popis: | Background: Pemphigus is a group of chronic blistering autoimmune diseases of which pemphigus vulgaris (PV) is the more frequent clinical form. The association of PV with the HLA serotypes suggests that there is a genetic predisposition to the disease. Objectives: To determine the frequency of class I and class II HLA antigens and the allelic variants of the class II HLA antigens, DR and DQ, in patients with PV and to determine the relative risk. Methods: An observational, prospective, transverse, and controlled study carried out between 1995 and 1999. Forty-seven patients with a diagnosis of PV and a control sampling of 199 unselected individuals from the same ethnic group were included. The HLA alleles were determined by polymerase chain reaction. Results: No significant associations were detected between HLA A, B, or C and our patients. The DR and DQ molecular alleles positively associated with PV were two different haplotypes: DRb1* 0402/DQb1* 0302 and DRb1* 1401/DQb1* 0503. Conclusions: In patients with the haplotype DRb1* 0402/DQb1* 0302 the affectation of 10%–30% of the corporal surface prevailed (ACS). In patients with DRb1* 1401/DRQb1* 0503, involvement of |
| Databáze: | OpenAIRE |
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