The clinical and pathological features of peripheral neuropathy accompanied with HTLV-I associated myelopathy
| Autor: | Takashiro Kiwaki, Kimiyoshi Arimura, Yumiko Arimura, S. Izumo, Fujio Umehara, Kayoko Itoh, Mitsuhiro Osame |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Pathology medicine.medical_specialty Sural nerve Human T-lymphotropic virus Central nervous system disease Myelopathy Sural Nerve immune system diseases hemic and lymphatic diseases Tropical spastic paraparesis medicine Humans Spasticity Myelin Sheath Aged Human T-lymphotropic virus 1 biology business.industry virus diseases Peripheral Nervous System Diseases Middle Aged Viral Load biology.organism_classification medicine.disease HTLV-I Infections Axons nervous system diseases Peripheral neuropathy Neurology Htlv i associated myelopathy Female sense organs Neurology (clinical) medicine.symptom business |
| Zdroj: | Journal of the neurological sciences. 206(1) |
| ISSN: | 0022-510X |
| Popis: | We describe the clinical and pathological studies in HTLV-I associated myelopathy (HAM)/tropical spastic paraparesis (TSP) patients with peripheral neuropathy as proven by sural nerve biopsy. Sural nerve pathology in HAM/TSP patients revealed that the most common type of pathologic change is a combination of both demyelination and remyelination and axonal degeneration and regeneration, and this change is modified by the complications. The pathologic changes were correlated with neither the duration of disease nor human T lymphotropic virus type I (HTLV-I) proviral load. This study suggests that peripheral nerves could be involved in HAM/TSP. |
| Databáze: | OpenAIRE |
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