Prognostic significance of the preoperative neutrophil-to-lymphocyte ratio patients with giant cell tumor of bone
| Autor: | İsmail Burak Atalay, Coşkun Ulucaköy, Mehmet Ali Tokgöz, Aliekber Yapar, Bedii Şafak Güngör |
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| Rok vydání: | 2021 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Neutrophils Lung metastasis Bone Neoplasms Gastroenterology Giant cell tumor of bone neutrophil-to-lymphocyte ratio prognostic significance Internal medicine medicine Humans In patient Lymphocytes Neutrophil to lymphocyte ratio Retrospective Studies Giant Cell Tumor of Bone Receiver operating characteristic medicine.diagnostic_test business.industry Proportional hazards model fungi Complete blood count General Medicine Prognosis medicine.disease Log-rank test business Giant-cell tumor of bone |
| Zdroj: | African Health Sciences; Vol. 21 No. 3 (2021); 1250-1258 |
| ISSN: | 1680-6905 |
| Popis: | Objective: To evaluate the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in giant cell tumor of bone (GCT). Methods: The patients with GCT were identified in the hospital records and pre-treatment complete blood count results were acquired retrospectively. Whether preoperative NLR lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) values had prognostic significance in predicting recurrence was evaluated by Receiver operating curve (ROC) analysis. Furthermore, the prognostic value of NLR was evaluated by Multivariable Cox Regression analysis. Results: There were 96 patients with GCT. It was found that only NLR values had prognostic significance for predicting recurrence (AUC:0.647; 95% CI:0.533-0.762; P=0.021). The statistically significant cut-off value of NLR for predicting re- currence was ≥2.25.NLR was ≥2.25 in 51% (n = 49) of patients. Multivariable analysis showed that NLR ≥2.25 (HR=2.9, 95% CI:1.3-6.6; p=0.009) and lung metastasis (HR=7.9, 95% CI:2.2-28.2; p=0.001) were independent factors of recurrence. In patients with lung metastasis and patients with NLR ≥2.25, recurrence was observed in a sooner period (Log rank test; p=0.001; p=0.009, respectively). Conclusion: Our findings showed that NLR is a new and promising inflammation-based prognostic factor in GCT patients. Keywords: Giant cell tumor of bone; neutrophil-to-lymphocyte ratio; prognostic significance. |
| Databáze: | OpenAIRE |
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