FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family

Autor: Barbara D. Wright, Henry B. Lowman, Ilona Holcomb, William J. Henzel, Gretchen Frantz, Caroline C. Hébert, Daniel Tumas, Franklin Peale, Thad Baker, David L. Shelton, Rhona C. Kabakoff, Austin L. Gurney, Betty Chan, Nicholas J. Skelton, Christopher Nelson
Rok vydání: 2000
Předmět:
Cell Survival
Molecular Sequence Data
Bronchi
Respiratory Mucosa
In situ hybridization
White adipose tissue
Biology
Calcitonin gene-related peptide
General Biochemistry
Genetics and Molecular Biology
Mice
Intestinal mucosa
Dorsal root ganglion
Sequence Analysis
Protein
Ganglia
Spinal
Nerve Growth Factor
Gene expression
Respiratory Hypersensitivity
medicine
Animals
Humans
Tissue Distribution
Amino Acid Sequence
Cysteine
Intestinal Mucosa
Molecular Biology
In Situ Hybridization
Sequence Homology
Amino Acid
General Immunology and Microbiology
Crypt Epithelium
General Neuroscience
Proteins
Sequence Analysis
DNA
Articles
Immunohistochemistry
Molecular biology
Rats
Nerve growth factor
medicine.anatomical_structure
nervous system
Multigene Family
Immunology
Intercellular Signaling Peptides and Proteins
Bronchoalveolar Lavage Fluid
Zdroj: The EMBO Journal. 19:4046-4055
ISSN: 0261-4189
DOI: 10.1093/emboj/19.15.4046
Popis: Bronchoalveolar lavage fluid from mice with experimentally induced allergic pulmonary inflammation contains a novel 9.4 kDa cysteine-rich secreted protein, FIZZ1 (found in inflammatory zone). Murine (m) FIZZ1 is the founding member of a new gene family including two other murine genes expressed, respectively, in intestinal crypt epithelium and white adipose tissue, and two related human genes. In control mice, FIZZ1 mRNA and protein expression occur at low levels in a subset of bronchial epithelial cells and in non-neuronal cells adjacent to neurovascular bundles in the peribronchial stroma, and in the wall of the large and small bowel. During allergic pulmonary inflammation, mFIZZ1 expression markedly increases in hypertrophic, hyperplastic bronchial epithelium and appears in type II alveolar pneumocytes. In vitro, recombinant mFIZZ1 inhibits the nerve growth factor (NGF)-mediated survival of rat embryonic day 14 dorsal root ganglion (DRG) neurons and NGF-induced CGRP gene expression in adult rat DRG neurons. In vivo, FIZZ1 may modulate the function of neurons innervating the bronchial tree, thereby altering the local tissue response to allergic pulmonary inflammation.
Databáze: OpenAIRE
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