Kidney Transplant Outcomes in elderly Recipients: An Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry Study
| Autor: | Armando Rogerió Martins Teixeira-Pinto, David W. Johnson, Yeoungjee Cho, Scott B. Campbell, Nicole M. Isbel, B. Doucet, Carmel M. Hawley |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Graft Rejection medicine.medical_specialty Adolescent health care facilities manpower and services medicine.medical_treatment Registry study Kidney transplant Young Adult Renal Dialysis Internal medicine medicine Humans Registries Elderly adults Dialysis Kidney transplantation Aged Transplantation Kidney business.industry Graft Survival Australia social sciences Middle Aged medicine.disease Kidney Transplantation Tissue Donors Transplant Recipients humanities Delayed Graft Function medicine.anatomical_structure Cohort Surgery business New Zealand |
| Zdroj: | Transplantation Proceedings. 53:1915-1926 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2021.06.024 |
| Popis: | Background There is an increase in elderly patients receiving kidney transplant internationally. This study describes elderly kidney transplant recipient outcomes in Australia and New Zealand. Methods The study included all adult first kidney transplant recipients in Australia and New Zealand from 2000 to 2015. Survival and graft outcomes were compared between elderly (≥70 years) and younger (18-69 years) recipients using Cox proportional hazards regression. Results Overall, 10651 kidney transplant recipients were included, of which 279 (2.6%) were elderly adults. The proportion of elderly recipients increased from 0.6 to 4.4% from 2000 to 2015. Compared with younger recipients, elderly recipients were more likely to receive kidneys from deceased donors, elderly donors, and expanded criteria donors. Elderly recipients experienced poorer patient survival with 1- and 5-year survival ranging from 96% to 97% and 79% to 81%, respectively, compared with 97% to 99% and 90% 95% in younger recipients, respectively. Elderly recipients experienced comparable rates of delayed graft function and, in living donor kidney recipients, lower rates of acute rejection. Conclusions Kidney transplantation in the elderly population is increasing. Although elderly recipients had inferior survival and graft outcomes, elderly recipients generally received poorer quality kidneys. The outcomes achieved in this cohort of elderly adults are encouraging, and improving elderly recipient outcomes should be an important focus for research. |
| Databáze: | OpenAIRE |
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