Regulation of Central Melanocortin Signaling by Interleukin-1β
| Autor: | Jarrad M. Scarlett, Pablo J. Enriori, Wilmon F. Grant, Ayesha K. Batra, Michael A. Cowley, Daniel L. Marks, Darren D Bowe, Erin E Jobst |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Pro-Opiomelanocortin Interleukin-1beta Cell Count Mice Transgenic Biology Eye Energy homeostasis Proinflammatory cytokine Rats Sprague-Dawley Mice Endocrinology Melanocortin receptor Central melanocortin system Proopiomelanocortin Genes Reporter Arcuate nucleus Internal medicine Weight Loss medicine Animals Inflammation digestive oral and skin physiology Anorexia Melanocortins Rats Mice Inbred C57BL medicine.anatomical_structure nervous system Hypothalamus biology.protein Cytokines Melanocortin Proto-Oncogene Proteins c-fos hormones hormone substitutes and hormone antagonists Signal Transduction |
| Zdroj: | Endocrinology. 148:4217-4225 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/en.2007-0017 |
| Popis: | Anorexia and involuntary weight loss are common and debilitating complications of a number of chronic diseases and inflammatory states. Proinflammatory cytokines, including IL-1 beta, are hypothesized to mediate these responses through direct actions on the central nervous system. However, the neural circuits through which proinflammatory cytokines regulate food intake and energy balance remain to be characterized. Here we report that IL-1 beta activates the central melanocortin system, a key neuronal circuit in the regulation of energy homeostasis. Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) were found to express the type I IL-1 receptor. Intracerebroventricular injection of IL-1 beta induced the expression of Fos protein in ARC POMC neurons but not in POMC neurons in the commissural nucleus of the tractus solitarius. We further show that IL-1 beta increases the frequency of action potentials of ARC POMC neurons and stimulates the release of alpha-MSH from hypothalamic explants in a dose-dependent fashion. Collectively, our data support a model in which IL-1 beta increases central melanocortin signaling by activating a subpopulation of hypothalamic POMC neurons and stimulating their release of alpha-MSH. |
| Databáze: | OpenAIRE |
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