Pregnant type 1 diabetes women with rises in C-peptide display higher levels of regulatory T cells: A pilot study
| Autor: | Michelle Rosenzwajg, Agnès Hartemann, Joe-Elie Salem, M. Popelier, M. Halbron, C. Ciangura, Fabrizio Andreelli, David Klatzmann, Olivier Bourron, S. Jacqueminet, E. Tibi, Chloé Amouyal |
|---|---|
| Přispěvatelé: | Rosenzwajg, Michelle |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Pregnancy in Diabetics Pilot Projects chemical and pharmacologic phenomena 030209 endocrinology & metabolism 030204 cardiovascular system & hematology T-Lymphocytes Regulatory Flow cytometry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Pregnancy Diabetes mellitus Internal medicine Internal Medicine medicine Humans Interleukine 2 Type 1 diabetes C-Peptide medicine.diagnostic_test C-peptide business.industry Insulin hemic and immune systems Regulatory T cells General Medicine medicine.disease [SDV] Life Sciences [q-bio] Diabetes Mellitus Type 1 Cytokine chemistry Cohort Interleukin-2 Female business C peptide |
| Zdroj: | Diabetes & Metabolism. 47:101188 |
| ISSN: | 1262-3636 |
| Popis: | Aim During pregnancy of type 1 diabetes (T1D) women, a C peptide rise has been described, which mechanism is unclear. In T1D, a defect of regulatory T cells (Tregs) and its major controlling cytokine, interleukin-2 (IL2), is observed. Methods Evolution of clinical, immunological (Treg (CD4+CD25hiCD127-/loFoxp3+ measured by flow cytometry and IL2 measured by luminex xMAP technology) and diabetes parameters (insulin dose per day, HbA1C, glycaemia, C peptide) was evaluated in 13 T1D women during the three trimesters of pregnancy and post-partum (PP, within 6 months) in a monocentric pilot study. Immunological parameters were compared with those of a healthy pregnant cohort (QuTe). Results An improvement of beta cell function (C peptide rise and/or a decrease of insulin dose-adjusted A1c index that estimate individual exogenous insulin need) was observed in seven women (group 1) whereas the six others (group 2) did not display any positive response to pregnancy. A higher level of Tregs and IL2 was observed in group 1 compared to group 2 during pregnancy and at PP for Tregs level. However, compared to the healthy cohort, T1D women displayed a Treg deficiency Conclusion This pilot study highlights that higher level of Tregs and IL2 seem to allow improvement of endogenous insulin secretion of T1D women during pregnancy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect