Impaired emotion processing in functional (psychogenic) tremor: A functional magnetic resonance imaging study
| Autor: | Matthew M. Norris, Jerzy P. Szaflarski, Alberto J. Espay, Jane B. Allendorfer, Jennifer Vannest, Anthony E. Lang, Thomas Maloney, James C. Eliassen, Erin Neefus |
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| Rok vydání: | 2018 |
| Předmět: |
Male
FSL FMRIB Software Library 0301 basic medicine Emotions lcsh:RC346-429 0302 clinical medicine Gyrus Functional tremor Cerebellum FT functional tremor Neural Pathways Tremor Brain Mapping MDEFT modified equilibrium Fourier transform Essential tremor medicine.diagnostic_test fMRI Brain Regular Article Middle Aged Magnetic Resonance Imaging Facial Expression medicine.anatomical_structure Neurology fMRI functional magnetic resonance imaging HAM-A Hamilton Anxiety Rating Scale lcsh:R858-859.7 Female Psychology Facial Recognition Adult Cognitive Neuroscience EPI echo-planar imaging HAM-D Hamilton Depression Rating Scale Emotion processing Motor Activity lcsh:Computer applications to medicine. Medical informatics 03 medical and health sciences Psychogenic tremor Functional movement disorders CPT-END continuous performance task with emotional and neutral distracters medicine Humans Psychogenic disease Radiology Nuclear Medicine and imaging Functional movement disorder lcsh:Neurology. Diseases of the nervous system Functional movement Aged AFNI Analysis of Functional Neuroimages Neural correlates of consciousness medicine.disease Cross-Sectional Studies 030104 developmental biology MINI Mini International Neuropsychiatric Interview FMRIB Software Library Conversion disorder Neurology (clinical) Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 17, Iss, Pp 179-187 (2018) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| Popis: | Background Despite its high prevalence and associated disability, the neural correlates of emotion processing in patients with functional (psychogenic) tremor (FT), the most common functional movement disorder, remain poorly understood. Methods In this cross sectional functional magnetic resonance imaging (fMRI) study at 4T, 27 subjects with FT, 16 with essential tremor (ET), and 25 healthy controls (HCs) underwent a finger-tapping motor task, a basic-emotion task, and an intense-emotion task to probe motor and emotion circuitries. Anatomical and functional MRI data were processed with FSL (FMRIB Software Library) and AFNI (Analysis of Functional Neuroimages), followed by seed-to-seed connectivity analyses using anatomical regions defined from the Harvard-Oxford subcortical atlas; all analyses were corrected for multiple comparisons. Results After controlling for depression scores and correcting for multiple comparisons, the FT group showed increased activation in the right cerebellum compared to ET during the motor task; and increased activation in the paracingulate gyrus and left Heschl's gyrus compared with HC with decreased activation in the right precentral gyrus compared with ET during the basic-emotion task. No significant differences were found after adjusting for multiple comparisons during the intense-emotion task but increase in connectivity between the left amygdala and left middle frontal gyrus survived corrections in the FT subjects during this task, compared to HC. Conclusions In response to emotional stimuli, functional tremor is associated with alterations in activation and functional connectivity in networks involved in emotion processing and theory of mind. These findings may be relevant to the pathophysiology of functional movement disorders. Highlights • Patients with functional tremor exhibit altered emotion processing circuitry. • There is increased activation in the paracingulate gyrus after emotional stimuli. • Increased connectivity between the left amygdala and middle frontal gyrus • Functional disorders may be associated with disturbances in the theory of mind. |
| Databáze: | OpenAIRE |
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