| Autor: |
Rana Abu-Dahab, Ola Tarawneh, Nour H. Aboalhaija, Sawsan Shraim, Alaaldin M. Alkilany, Shrouq Alsotari, Nouf N. Mahmoud, Enam A. Khalil, Haneen Qabooq |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
RSC advances. 11(33) |
| ISSN: |
2046-2069 |
| Popis: |
Herein, a polymeric nanofiber scaffold loaded with Quercetin (Quer)–gold nanorods (GNR) was developed and characterized. Several parameters related to loading Quer into GNR, incorporating the GNR-Quer into polymeric solutions, and fabricating the nanofibers by electrospinning were optimized. GNR-Quer loaded into a polymeric mixture of poly(lactic-co-glycolic acid) (PLGA) (21%) and poloxamer 407 (23%) has produced intact GNR-Quer-nanofibers with enhanced physical and mechanical properties. GNR-Quer-nanofibers demonstrated a slow pattern of Quer release over time compared to nanofibers free of GNR-Quer. Dynamic mechanical thermal analysis (DMTA) revealed enhanced uniformity and homogeneity of the GNR-Quer-nanofibers. GNR-Quer-nanofibers demonstrated a high ability to retain water upon incubation in phosphate buffer saline (PBS) for 24 h compared to nanofibers free of GNR-Quer. A cellular toxicity study indicated that the average cellular viability of human dermal fibroblasts was 76% after 24 h of exposure to the nanofibers containing a low concentration of GNR-Quer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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