Nodular Lymphocyte Predominance Hodgkin's Disease: Long-Term Observation Reveals a Continuous Pattern of Recurrence
Autor: | Mario Lazzarino, Carlo Bernasconi, Ester Orlandi, Umberto Magrini, Cesare Astori, Ercole Brusamolino, Marco Paulli |
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Rok vydání: | 1997 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Lymphocyte Disease Gastroenterology hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans music Lymph node Aged Aged 80 and over Chemotherapy music.instrument business.industry Hematology Middle Aged medicine.disease Hodgkin Disease Follicular hyperplasia Lymphoma Surgery Radiation therapy Treatment Outcome medicine.anatomical_structure Oncology Localized disease Female Neoplasm Recurrence Local business Follow-Up Studies |
Zdroj: | Leukemia & Lymphoma. 26:359-368 |
ISSN: | 1029-2403 1042-8194 |
Popis: | We evaluated the presenting clinical characteristics and outcome of 68 patients with nodular lymphocyte predominance Hodgkin's disease (NLP-HD), in order to delineate the pattern of evolution of the disease. The male to female ratio was 46/22 and median age 35 yrs (range, 14-86). Eight patients had a history of benign hyperplasia on lymph node biopsies performed 6 to 36 months before the diagnosis of NLP-HD. Early stage disease accounted for 75% of cases. One patient had a coexistent non-Hodgkin's lymphoma (NHL). Treatment was as follows: radiotherapy in 26, chemotherapy in 23, combined modality in 19. CR rate was 93% (63/68). 18 patients relapsed as HD and 5 developed NHL. The cumulative risk of NHL was 9% at 10 yrs. During remission, 4 patients had 5 episodes of follicular hyperplasia histologically documented. Overall survival rate was 71% at 10 yrs and and 63% at 15 yrs. Freedom from progression (FFP) declined from 67% at 5 yrs to 45% at 10 yrs, because of late relapses. Localized disease predicted for a better FFP (p = 0.01), but was not associated with a reduced risk of recurrence over time. NLP-HD is characterized by an indolent course with a constant pattern of relapse over time, also in patients with early stage disease at diagnosis. In addition to relapse as NLP-HD, patients may evolve into a NHL or develop benign lymph nodal hyperplasia. Careful long-term follow up is needed for these patients. |
Databáze: | OpenAIRE |
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